Philipp Beckhove
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Explore the profile of Philipp Beckhove including associated specialties, affiliations and a list of published articles.
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132
Citations
5780
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Recent Articles
11.
Spoerl S, Erber R, Gerken M, Taxis J, Ludwig N, Nieberle F, et al.
Cancers (Basel)
. 2023 Feb;
15(3).
PMID: 36765630
A20, known as a potent inhibitor of NF-κB signaling, has been characterized in numerous clinical as well as preclinical studies. Recently, especially in various malignant diseases, the prognostic and therapeutic...
12.
Sorrentino A, Menevse A, Michels T, Volpin V, Durst F, Sax J, et al.
J Immunother Cancer
. 2022 May;
10(5).
PMID: 35606086
Background: Cancer immunotherapeutic strategies showed unprecedented results in the clinic. However, many patients do not respond to immuno-oncological treatments due to the occurrence of a plethora of immunological obstacles, including...
13.
Hassel J, Schank T, Smetak H, Muhlbauer J, Salzmann M, Machiraju D, et al.
Oncoimmunology
. 2022 Apr;
11(1):2066609.
PMID: 35481285
In patients with melanoma brain metastases (MBM), a combination of radiotherapy (RT) with immune checkpoint inhibitors (ICI) is routinely used. However, the best sequence of radio-immunotherapy (RIT) remains unclear. In...
14.
Walle T, Kraske J, Liao B, Lenoir B, Timke C, von Bohlen Und Halbach E, et al.
Sci Adv
. 2022 Mar;
8(12):eabh4050.
PMID: 35319989
Radiotherapy is a mainstay cancer therapy whose antitumor effects partially depend on T cell responses. However, the role of Natural Killer (NK) cells in radiotherapy remains unclear. Here, using a...
15.
Pinkert J, Boehm H, Trautwein M, Doecke W, Wessel F, Ge Y, et al.
Oncoimmunology
. 2022 Feb;
11(1):2008110.
PMID: 35141051
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6), a cell surface receptor, is expressed on normal epithelial tissue and highly expressed in cancers of high unmet medical need, such as non-small...
16.
Stamova S, Ott-Rotzer B, Smetak H, Schaffler K, Eder R, Fink I, et al.
J Immunol Methods
. 2021 Jun;
496:113086.
PMID: 34146580
Rare subpopulations of tumor antigen-reactive memory T cells, which actively secrete type-1 effector cytokines, particularly TNF-α in situ, possess anti-tumor activity and prognostic relevance. These cells are relevant for cancer...
17.
Sattler C, Hoffmann P, Herzberg P, Weber D, Holler B, Fehn U, et al.
Vaccine
. 2021 May;
39(33):4742-4750.
PMID: 34049733
Allogeneic hematopoietic stem cell transplantation (alloHSCT) results in a loss of humoral immunity and subsequent risk for severe infections. Thus, re-vaccination is required but may fail due to incomplete immune...
18.
Xydia M, Rahbari R, Ruggiero E, Macaulay I, Tarabichi M, Lohmayer R, et al.
Nat Commun
. 2021 Feb;
12(1):1119.
PMID: 33602930
Regulatory CD4 T cells (Treg) prevent tumor clearance by conventional T cells (Tconv) comprising a major obstacle of cancer immune-surveillance. Hitherto, the mechanisms of Treg repertoire formation in human cancers...
19.
Spanier G, Ugele I, Nieberle F, Symeou L, Schmidhofer S, Brand A, et al.
Cancer Lett
. 2020 Dec;
499:209-219.
PMID: 33276040
Diabetes mellitus type II (DM) and immune cell infiltration determine patient outcome in many tumor entities. Here we studied a possible link between the metabolic and immune cell status of...
20.
Safi S, Yamauchi Y, Hoffmann H, Weichert W, Jost P, Winter H, et al.
Cancers (Basel)
. 2020 Dec;
12(12).
PMID: 33255425
Spontaneous T cell responses to tumor-associated antigens (TAs) in the peripheral blood of patients with non-small-cell lung cancer (NSCLC) may be relevant for postoperative survival. However, the conditions underlying these...