Philip S Crooke 3rd
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Explore the profile of Philip S Crooke 3rd including associated specialties, affiliations and a list of published articles.
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13
Citations
252
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Recent Articles
1.
Crooke 3rd P, Tossberg J, Aune T
J Alzheimers Dis
. 2025 Jan;
103(4):1216-1225.
PMID: 39865681
Background: Endogenous Alu RNAs form double-stranded RNAs recognized by double-stranded RNA sensors and activate IRF and NF-kB transcriptional paths and innate immunity. Deamination of adenosines to inosines by the ADAR...
2.
Garland K, Kwiatkowski A, Tossberg J, Crooke 3rd P, Aune T, Wilson J
Cancer Res Commun
. 2023 Sep;
3(9):1800-1809.
PMID: 37691856
Significance: Loss of A-to-I editing leads to accumulation of unedited Alu RNAs that activate innate immunity via RNA-sensing pattern recognition receptors. When packaged into endosome-releasing polymer nanoparticles, AluJB RNA becomes...
3.
Crooke 3rd P, Tossberg J, Heinrich R, Porter K, Aune T
Brain Commun
. 2022 Oct;
4(5):fcac238.
PMID: 36196083
Alzheimer's disease is the most common form of dementia and recent studies identify a type 1 interferon response in Alzheimer's disease possibly driving neuro-inflammation and other Alzheimer's disease pathologies. Loss...
4.
Patrick A, Shoaff K, Esmond T, Patrick D, Flaherty D, Graham T, et al.
Front Immunol
. 2022 Jul;
13:848168.
PMID: 35860254
In juvenile idiopathic arthritis (JIA) inflammatory T cells and their produced cytokines are drug targets and play a role in disease pathogenesis. Despite their clinical importance, the sources and types...
5.
Aune T, Tossberg J, Heinrich R, Porter K, Crooke 3rd P
Front Immunol
. 2022 Feb;
13:818023.
PMID: 35126398
Alu retrotransposons belong to the class of short interspersed nuclear elements (SINEs). Alu RNA is abundant in cells and its repetitive structure forms double-stranded RNAs (dsRNA) that activate dsRNA sensors...
6.
Crooke 3rd P, Tossberg J, Porter K, Aune T
Curr Res Immunol
. 2021 May;
2:52-59.
PMID: 33969287
Due to potential severity of disease caused by SARS-CoV-2 infection, it is critical to understand both mechanisms of viral pathogenesis as well as diversity of host responses to infection. Reduced...
7.
Cutting Edge: Reduced Adenosine-to-Inosine Editing of Endogenous Alu RNAs in Severe COVID-19 Disease
Crooke 3rd P, Tossberg J, Porter K, Aune T
J Immunol
. 2021 Mar;
206(8):1691-1696.
PMID: 33782089
Severe COVID-19 disease is associated with elevated inflammatory responses. One form of Aicardi-Goutières syndrome caused by inactivating mutations in results in reduced adenosine-to-inosine (A-to-I) editing of endogenous dsRNAs, induction of...
8.
Tossberg J, Heinrich R, Farley V, Crooke 3rd P, Aune T
J Immunol
. 2020 Oct;
205(10):2606-2617.
PMID: 33046502
Sensors that detect dsRNA stimulate IFN responses as a defense against viral infection. IFN responses are also well documented in a variety of human autoimmune diseases, including relapsing-remitting multiple sclerosis...
9.
Heinrich M, Purcell C, Pruijssers A, Zhao Y, Spurlock 3rd C, Sriram S, et al.
J Autoimmun
. 2019 Mar;
100:40-51.
PMID: 30826177
Various sensors that detect double-stranded RNA, presumably of viral origin, exist in eukaryotic cells and induce IFN-responses. Ongoing IFN-responses have also been documented in a variety of human autoimmune diseases...
10.
Spurlock 3rd C, Shaginurova G, Tossberg J, Hester J, Chapman N, Guo Y, et al.
J Immunol
. 2017 Jun;
199(2):547-558.
PMID: 28600289
We employed whole-genome RNA-sequencing to profile mRNAs and both annotated and novel long noncoding RNAs (lncRNAs) in human naive, central memory, and effector memory CD4 T cells. Loci transcribing both...