Philip L Leopold
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Explore the profile of Philip L Leopold including associated specialties, affiliations and a list of published articles.
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49
Citations
1558
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Recent Articles
1.
Gunaydin C, Sondhi D, Kaminsky S, Lephart H, Leopold P, Hackett N, et al.
Mol Ther
. 2024 Nov;
32(12):4303-4318.
PMID: 39511891
Gene therapy to treat hereditary disorders conventionally delivers the normal allele to compensate for loss-of-function mutations. More effective gene therapy may be achieved using a gain-of-function variant. We tested the...
2.
Rostami M, Leopold P, Vasquez J, de Mulder Rougvie M, Al Shakaki A, Ait Hssain A, et al.
Mol Ther Methods Clin Dev
. 2023 Dec;
31:101136.
PMID: 38089635
Based on the observation that humans have variable responses of gene expression with the same dose of an adeno-associated vector, we hypothesized that there are deleterious variants in genes coding...
3.
Reeve G, Rostami M, Reich R, Behrman D, Leopold P, Crystal R, et al.
J Oral Pathol Med
. 2022 Oct;
52(5):431-439.
PMID: 36300726
Background: Electronic cigarettes are increasing in popularity, but there is only little information on their biologic effects on the oral epithelium, the initial site exposed to electronic cigarette smoke. Methods:...
4.
Rostami M, LeBlanc M, Strulovici-Barel Y, Zuo W, Mezey J, OBeirne S, et al.
NPJ Genom Med
. 2021 Sep;
6(1):73.
PMID: 34497273
The club cell, a small airway epithelial (SAE) cell, plays a central role in human lung host defense. We hypothesized that subpopulations of club cells with distinct functions may exist....
5.
Nathan S, Zhang H, Andreoli M, Leopold P, Crystal R
Respir Res
. 2021 Apr;
22(1):97.
PMID: 33794877
Background: Lysophosphatidic acid (LPA), generated extracellularly by the action of autotaxin and phospholipase A2, functions through LPA receptors (LPARs) or sphingosine-1-phosphate receptors (S1PRs) to induce pro-fibrotic signaling in the lower...
6.
Zuo W, Rostami M, LeBlanc M, Kaner R, OBeirne S, Mezey J, et al.
PLoS One
. 2020 Sep;
15(9):e0237529.
PMID: 32941426
Idiopathic pulmonary fibrosis (IPF) is a progressive, chronic fibrotic lung disease with an irreversible decline of lung function. "Bronchiolization", characterized by ectopic appearance of airway epithelial cells in the alveolar...
7.
Zhang H, Rostamim M, Leopold P, Mezey J, OBeirne S, Strulovici-Barel Y, et al.
Am J Respir Crit Care Med
. 2020 Aug;
202(7):1056-1057.
PMID: 32749854
No abstract available.
8.
Zuo W, Rostami M, Shenoy S, LeBlanc M, Salit J, Strulovici-Barel Y, et al.
Respir Res
. 2020 Jul;
21(1):200.
PMID: 32727470
Background: The human small airway epithelium (SAE) plays a central role in the early events in the pathogenesis of most inherited and acquired lung disorders. Little is known about the...
9.
Zhang H, Rostami M, Leopold P, Mezey J, OBeirne S, Strulovici-Barel Y, et al.
Am J Respir Crit Care Med
. 2020 May;
202(2):219-229.
PMID: 32432483
Infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease (COVID-19), a predominantly respiratory illness. The first step in SARS-CoV-2 infection is binding of the virus to...
10.
Zhu D, Rostami M, Zuo W, Leopold P, Crystal R
Hum Gene Ther
. 2020 Mar;
31(9-10):590-604.
PMID: 32143547
Capitalizing on liver tropism of adeno-associated viral (AAV) vectors, intravenous vector administration is commonly used to genetically modify hepatocytes, a strategy currently in clinical trials for a number of liver-based...