Philip L Felgner
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Explore the profile of Philip L Felgner including associated specialties, affiliations and a list of published articles.
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173
Citations
6403
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Recent Articles
1.
Ouattara A, Andronescu L, Adams M, Sharma A, Nakajima R, Jain A, et al.
Open Forum Infect Dis
. 2025 Feb;
12(2):ofaf037.
PMID: 39963702
While sulfadoxine-pyrimethamine has been the primary drug in intermittent preventive treatment in pregnancy, dihydroartemisinin-piperaquine (DP) is being considered as an alternative. DP may lead to lower antimalarial antibodies in the...
2.
Holubowicz R, Du S, Felgner J, Smidak R, Choi E, Palczewska G, et al.
Nat Biomed Eng
. 2024 Nov;
9(1):57-78.
PMID: 39609561
Delivering ribonucleoproteins (RNPs) for in vivo genome editing is safer than using viruses encoding for Cas9 and its respective guide RNA. However, transient RNP activity does not typically lead to...
3.
Tumbo A, Lorenz F, Yang A, Sefried S, Schindler T, Mpina M, et al.
EBioMedicine
. 2024 Oct;
108:105364.
PMID: 39353279
Background: PfSPZ Vaccine, a promising pre-erythrocytic stage malaria vaccine candidate based on whole, radiation-attenuated Plasmodium falciparum (Pf) sporozoites (SPZ), has proven safe and effective in mediating sterile protection from malaria...
4.
Bailey R, Lawton J, Niangaly A, Stucke E, Bailey J, Berry A, et al.
J Infect
. 2024 Aug;
89(4):106257.
PMID: 39216830
Children with hemoglobin AC or AS have decreased susceptibility to clinical malaria. Parasite variant surface antigen (VSA) presentation on the surface of infected erythrocytes is altered in erythrocytes with hemoglobin...
5.
Wistuba-Hamprecht J, Reuter B, Fendel R, Hoffman S, Campo J, Felgner P, et al.
PLoS Comput Biol
. 2024 Jun;
20(6):e1012131.
PMID: 38848436
Immunization through repeated direct venous inoculation of Plasmodium falciparum (Pf) sporozoites (PfSPZ) under chloroquine chemoprophylaxis, using the PfSPZ Chemoprophylaxis Vaccine (PfSPZ-CVac), induces high-level protection against controlled human malaria infection (CHMI)....
6.
Lopez-Perez M, Jain A, Davies D, Vasquez-Jimenez J, Herrera S, Onate J, et al.
Sci Rep
. 2024 Feb;
14(1):2790.
PMID: 38307966
Malaria sterile immunity has been reproducibly induced by immunization with Plasmodium radiation-attenuated sporozoites (RAS). Analyses of sera from RAS-immunized individuals allowed the identification of P. falciparum antigens, such as the...
7.
Tewey M, Coulibaly D, Lawton J, Stucke E, Zhou A, Berry A, et al.
mSphere
. 2023 Oct;
8(5):e0045123.
PMID: 37791774
Antibody responses to variant surface antigens (VSAs) produced by the malaria parasite may contribute to age-related natural immunity to severe malaria. One VSA family, erythrocyte membrane protein-1 (PfEMP1), includes a...
8.
Emami M, Espinoza A, Young C, Ma F, Farahat P, Felgner P, et al.
Mol Ther Methods Clin Dev
. 2023 Sep;
30:90-102.
PMID: 37746243
High systemic doses of adeno-associated viruses (AAVs) have been associated with immune-related serious adverse events (SAEs). Although AAV was well tolerated in preclinical models, SAEs were observed in clinical trials,...
9.
Ramirez A, Felgner J, Jain A, Jan S, Albin T, Badten A, et al.
Bioconjug Chem
. 2023 Sep;
34(9):1653-1666.
PMID: 37682243
is the causative agent of Q fever, for which there is yet to be an FDA-approved vaccine. This bacterial pathogen has both extra- and intracellular stages in its life cycle,...
10.
Martinaud C, Bagri A, Tsai C, de Assis R, Gatmaitan M, Robinson P, et al.
Transfusion
. 2023 Aug;
63(9):1633-1638.
PMID: 37615329
Background: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-infected patients exhibit disease ranging from asymptomatic to severe pneumonia, multi-organ failure, and death. convalescent COVID plasma (CCP) from recovered patients with high levels...