Philip J Starkey Lewis
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Explore the profile of Philip J Starkey Lewis including associated specialties, affiliations and a list of published articles.
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18
Citations
667
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Recent Articles
1.
Candela M, Addison M, Aird R, Man T, Cartwright J, Ashmore-Harris C, et al.
NPJ Regen Med
. 2025 Jan;
10(1):5.
PMID: 39843512
Acute liver failure is a rapidly progressing, life-threatening condition most commonly caused by an overdose of acetaminophen (paracetamol). The antidote, N-acetylcysteine (NAC), has limited efficacy when liver injury is established....
2.
Hallett J, Ferreira-Gonzalez S, Man T, Kilpatrick A, Esser H, Thirlwell K, et al.
Cell Stem Cell
. 2022 Mar;
29(3):355-371.e10.
PMID: 35245467
Biliary diseases can cause inflammation, fibrosis, bile duct destruction, and eventually liver failure. There are no curative treatments for biliary disease except for liver transplantation. New therapies are urgently required....
3.
Meseguer-Ripolles J, Lucendo-Villarin B, Tucker C, Ferreira-Gonzalez S, Homer N, Wang Y, et al.
iScience
. 2021 Jun;
24(6):102552.
PMID: 34151225
Liver disease is a major cause of premature death. Oxidative stress in the liver represents a key disease driver. Compounds, such as dimethyl fumarate (DMF), can activate the antioxidant response...
4.
Chan B, Elmasry M, Forootan S, Russomanno G, Bunday T, Zhang F, et al.
Hepatology
. 2021 Apr;
74(2):973-986.
PMID: 33872408
Background And Aims: The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) regulates an array of cytoprotective genes, yet studies in transgenic mice have led to conflicting reports on...
5.
Alwahsh S, Qutachi O, Starkey Lewis P, Bond A, Noble J, Burgoyne P, et al.
Am J Transplant
. 2021 Jan;
21(9):2950-2963.
PMID: 33428803
Transplantation of islets in type 1 diabetes (T1D) is limited by poor islet engraftment into the liver, with two to three donor pancreases required per recipient. We aimed to condition...
6.
Dwyer B, Jarman E, Gogoi-Tiwari J, Ferreira-Gonzalez S, Boulter L, Guest R, et al.
J Hepatol
. 2020 Nov;
74(4):860-872.
PMID: 33221352
Background & Aims: Cholangiocarcinoma (CCA) is a cancer of the hepatic bile ducts that is rarely resectable and is associated with poor prognosis. Tumour necrosis factor-like weak inducer of apoptosis...
7.
Laurent D, Semple F, Starkey Lewis P, Rose E, Black H, Coe J, et al.
BMC Med Genomics
. 2020 Apr;
13(1):60.
PMID: 32252771
Background: Despite the emergence of cell-free DNA (cfDNA) as a clinical biomarker in cancer, the tissue origins of cfDNA in healthy individuals have to date been inferred only by indirect...
8.
Starkey Lewis P, Moroni F, Forbes S
Semin Liver Dis
. 2019 Jun;
39(4):442-451.
PMID: 31242527
Liver failure arising from acute and chronic liver disease is an unmet clinical need that urgently requires novel therapeutic options in addition to orthotopic liver transplantation. Cell therapies offer new...
9.
Watanabe Y, Tsuchiya A, Seino S, Kawata Y, Kojima Y, Ikarashi S, et al.
Stem Cells Transl Med
. 2018 Nov;
8(3):271-284.
PMID: 30394698
We describe a novel therapeutic approach for cirrhosis using mesenchymal stem cells (MSCs) and colony-stimulating factor-1-induced bone marrow-derived macrophages (id-BMMs) and analyze the mechanisms underlying fibrosis improvement and regeneration. Mouse...
10.
Ferreira-Gonzalez S, Lu W, Raven A, Dwyer B, Man T, ODuibhir E, et al.
Nat Commun
. 2018 Mar;
9(1):1020.
PMID: 29523787
Cellular senescence is a mechanism that provides an irreversible barrier to cell cycle progression to prevent undesired proliferation. However, under pathological circumstances, senescence can adversely affect organ function, viability and...