Philip Hallenborg
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Explore the profile of Philip Hallenborg including associated specialties, affiliations and a list of published articles.
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23
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926
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Recent Articles
1.
Boel F, Akimov V, Teuchler M, Terkelsen M, Wernberg C, Larsen F, et al.
Commun Med (Lond)
. 2025 Mar;
5(1):56.
PMID: 40032974
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) affects roughly 1 in 3 adults and is a leading cause of liver transplants and liver related mortality. A deeper understanding of disease...
2.
Bendixen S, Jakobsgaard P, Hansen D, Hejn K, Terkelsen M, Bjerre F, et al.
J Hepatol
. 2023 Nov;
80(3):467-481.
PMID: 37972658
Background & Aims: Metabolic dysfunction-associated steatohepatitis (MASH) is linked to insulin resistance and type 2 diabetes and marked by hepatic inflammation, microvascular dysfunction, and fibrosis, impairing liver function and aggravating...
3.
Lin H, Wang L, Liu Z, Long K, Kong M, Ye D, et al.
Adv Sci (Weinh)
. 2022 May;
9(20):e2200742.
PMID: 35524581
Dysfunctional triglyceride-very low-density lipoprotein (TG-VLDL) metabolism is linked to metabolic-associated fatty liver disease (MAFLD); however, the underlying cause remains unclear. The study shows that hepatic E3 ubiquitin ligase murine double...
4.
Hallenborg P, Jensen B, Fjaere E, Petersen R, Belmaati M, Rasmussen S, et al.
Sci Rep
. 2021 Nov;
11(1):21839.
PMID: 34750429
The intimate association between obesity and type II diabetes urges for a deeper understanding of adipocyte function. We and others have previously delineated a role for the tumor suppressor p53...
5.
Agidius H, Veidal S, Feigh M, Hallenborg P, Puglia M, Pers T, et al.
Sci Rep
. 2020 Jan;
10(1):1148.
PMID: 31980690
To improve the understanding of the complex biological processes underlying the development of non-alcoholic steatohepatitis (NASH), a multi-omics approach combining bulk RNA-sequencing based transcriptomics, quantitative proteomics and single-cell RNA-sequencing was...
6.
Barrio-Hernandez I, Jafari A, Rigbolt K, Hallenborg P, Sanchez-Quiles V, Skovrind I, et al.
Genome Res
. 2019 Dec;
30(1):127-137.
PMID: 31831592
Bone marrow-derived mesenchymal stem cells (MSCs) differentiate into osteoblasts upon stimulation by signals present in their niche. Because the global signaling cascades involved in the early phases of MSCs osteoblast...
7.
Liu Z, Jin L, Yang J, Wang B, Wu K, Hallenborg P, et al.
Diabetes
. 2018 Aug;
67(11):2397-2409.
PMID: 30131393
Profound loss and senescence of adipose tissues are hallmarks of advanced age, but the underlying cause and their metabolic consequences remain obscure. Proper function of the murine double minute 2...
8.
Akimov V, Barrio-Hernandez I, Hansen S, Hallenborg P, Pedersen A, Bekker-Jensen D, et al.
Nat Struct Mol Biol
. 2018 Jul;
25(7):631-640.
PMID: 29967540
Ubiquitination is a post-translational modification (PTM) that is essential for balancing numerous physiological processes. To enable delineation of protein ubiquitination at a site-specific level, we generated an antibody, denoted UbiSite,...
9.
Li X, Cheng K, Liu Z, Yang J, Wang B, Jiang X, et al.
Nat Commun
. 2016 Jun;
7:11740.
PMID: 27265727
Mitochondrial metabolism is pivotal for glucose-stimulated insulin secretion (GSIS) in pancreatic β-cells. However, little is known about the molecular machinery that controls the homeostasis of intermediary metabolites in mitochondria. Here...
10.
Hallenborg P, Petersen R, Kouskoumvekaki I, Newman J, Madsen L, Kristiansen K
Prog Lipid Res
. 2015 Dec;
61:149-62.
PMID: 26703188
The nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) is the key decisive factor controlling the development of adipocytes. Ligand-mediated activation of PPARγ occurs early during adipogenesis and is thought to...