Philip Garrett-Engele
Overview
Explore the profile of Philip Garrett-Engele including associated specialties, affiliations and a list of published articles.
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10
Citations
5784
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Recent Articles
1.
Derti A, Garrett-Engele P, MacIsaac K, Stevens R, Sriram S, Chen R, et al.
Genome Res
. 2012 Mar;
22(6):1173-83.
PMID: 22454233
We developed PolyA-seq, a strand-specific and quantitative method for high-throughput sequencing of 3' ends of polyadenylated transcripts, and used it to globally map polyadenylation (polyA) sites in 24 matched tissues...
2.
Babak T, Garrett-Engele P, Armour C, Raymond C, Keller M, Chen R, et al.
BMC Genomics
. 2010 Aug;
11:473.
PMID: 20707912
Background: Identifying associations between genotypes and gene expression levels using microarrays has enabled systematic interrogation of regulatory variation underlying complex phenotypes. This approach has vast potential for functional characterization of...
3.
Castle J, Hara Y, Raymond C, Garrett-Engele P, Ohwaki K, Kan Z, et al.
PLoS One
. 2009 Feb;
4(2):e4369.
PMID: 19190759
Acetyl-CoA carboxylases ACC1 and ACC2 catalyze the carboxylation of acetyl-CoA to malonyl-CoA, regulating fatty-acid synthesis and oxidation, and are potential targets for treatment of metabolic syndrome. Expression of ACC1 in...
4.
Grimson A, Farh K, Johnston W, Garrett-Engele P, Lim L, Bartel D
Mol Cell
. 2007 Jul;
27(1):91-105.
PMID: 17612493
Mammalian microRNAs (miRNAs) pair to 3'UTRs of mRNAs to direct their posttranscriptional repression. Important for target recognition are approximately 7 nt sites that match the seed region of the miRNA....
5.
Cheung Y, Kan Z, Garrett-Engele P, Gall I, Murdoch H, Baillie G, et al.
J Pharmacol Exp Ther
. 2007 May;
322(2):600-9.
PMID: 17519386
The cAMP-specific phosphodiesterase-4 (PDE4) gene family is the target of several potential selective therapeutic inhibitors. The four PDE4 genes generate several distinct protein-coding isoforms through the use of alternative promoters...
6.
Lim L, Lau N, Garrett-Engele P, Grimson A, Schelter J, Castle J, et al.
Nature
. 2005 Feb;
433(7027):769-73.
PMID: 15685193
MicroRNAs (miRNAs) are a class of noncoding RNAs that post-transcriptionally regulate gene expression in plants and animals. To investigate the influence of miRNAs on transcript levels, we transfected miRNAs into...
7.
Raymond C, Castle J, Garrett-Engele P, Armour C, Kan Z, Tsinoremas N, et al.
J Biol Chem
. 2004 Aug;
279(44):46234-41.
PMID: 15302875
Molecular medicine requires the precise definition of drug targets, and tools are now in place to provide genome-wide information on the expression and alternative splicing patterns of any known gene....
8.
Lum P, Armour C, Stepaniants S, Cavet G, Wolf M, Butler J, et al.
Cell
. 2004 Jan;
116(1):121-37.
PMID: 14718172
Modern medicine faces the challenge of developing safer and more effective therapies to treat human diseases. Many drugs currently in use were discovered without knowledge of their underlying molecular mechanisms....
9.
Johnson J, Castle J, Garrett-Engele P, Kan Z, Loerch P, Armour C, et al.
Science
. 2003 Dec;
302(5653):2141-4.
PMID: 14684825
Alternative pre-messenger RNA (pre-mRNA) splicing plays important roles in development, physiology, and disease, and more than half of human genes are alternatively spliced. To understand the biological roles and regulation...
10.
Wright R, L Parrish M, Cadera E, Larson L, Matson C, Garrett-Engele P, et al.
Yeast
. 2003 Jul;
20(10):881-92.
PMID: 12868057
Increased levels of HMG-CoA reductase induce cell type- and isozyme-specific proliferation of the endoplasmic reticulum. In yeast, the ER proliferations induced by Hmg1p consist of nuclear-associated stacks of smooth ER...