Philip Fitchev
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Explore the profile of Philip Fitchev including associated specialties, affiliations and a list of published articles.
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17
Citations
227
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Recent Articles
1.
Lanman N, Meco E, Fitchev P, Kolliegbo A, Broman M, Filipovich Y, et al.
Front Immunol
. 2025 Jan;
15:1494476.
PMID: 39867899
Introduction: Macrophages exhibit marked phenotypic heterogeneity within and across disease states, with lipid metabolic reprogramming contributing to macrophage activation and heterogeneity. Chronic inflammation has been observed in human benign prostatic...
2.
Lanman N, Meco E, Fitchev P, Kolliegbo A, Broman M, Filipovich Y, et al.
bioRxiv
. 2024 Jun;
PMID: 38915654
Macrophages exhibit marked phenotypic heterogeneity within and across disease states, with lipid metabolic reprogramming contributing to macrophage activation and heterogeneity. Chronic inflammation has been observed in human benign prostatic hyperplasia...
3.
Nardi F, Fitchev P, Brooks K, Franco O, Cheng K, Hayward S, et al.
Lab Invest
. 2019 Aug;
99(12):1822-1834.
PMID: 31409893
Lipid droplets (LDs) utilize microtubules (MTs) to participate in intracellular trafficking of cargo proteins. Cancer cells accumulate LDs and acidify their tumor microenvironment (TME) by increasing the proton pump V-ATPase....
4.
Influence of maternal obesity and metabolic and vascular mediators in twin-twin transfusion syndrome
Starnes S, Nardi F, Fitchev P, Plunkett B, Thorpe C, Wang C, et al.
Reprod Biol
. 2019 Jun;
19(2):165-172.
PMID: 31147266
Obesity is a risk factor for complications in singleton and twin pregnancies; however, there are limited data regarding maternal body mass index (BMI) in the setting of twin-twin transfusion syndrome...
5.
Nardi F, Franco O, Fitchev P, Morales A, Vickman R, Hayward S, et al.
Sci Rep
. 2019 Mar;
9(1):3035.
PMID: 30816200
Acyl-CoA:diacylglycerol acyltransferase I (DGAT1) is a key enzyme in lipogenesis which is increased in metabolically active cells to meet nutrient requirements. DGAT1 has been recognized as an anti-obesity target; however,...
6.
Nardi F, Fitchev P, Franco O, Ivanisevic J, Scheibler A, Hayward S, et al.
J Cell Sci
. 2018 May;
131(13).
PMID: 29792311
Prostate tumors make metabolic adaptations to ensure adequate energy and amplify cell cycle regulators, such as centrosomes, to sustain their proliferative capacity. It is not known whether cancer-associated fibroblasts (CAFs)...
7.
Filipovich Y, Agrawal V, Crawford S, Fitchev P, Qu X, Klein J, et al.
Am J Obstet Gynecol
. 2015 Jul;
213(5):697.e1-10.
PMID: 26215328
Objective: The objective of the study was to investigate the role of polymorphonuclear leukocytes (PMNs) in a mouse model of Escherichia coli-induced labor. Study Design: Intraperitoneal injection of rabbit antimouse...
8.
Tong X, Mirzoeva S, Veliceasa D, Bridgeman B, Fitchev P, Cornwell M, et al.
Oncotarget
. 2014 Dec;
5(22):11413-27.
PMID: 25526033
Plant flavonoid apigenin prevents and inhibits UVB-induced carcinogenesis in the skin and has strong anti-proliferative and anti-angiogenic properties. Here we identify mechanisms, by which apigenin controls these oncogenic events. We...
9.
Loss of the cytoskeletal protein Pdlim7 predisposes mice to heart defects and hemostatic dysfunction
Krcmery J, Gupta R, Sadleir R, Ahrens M, Misener S, Kamide C, et al.
PLoS One
. 2013 Nov;
8(11):e80809.
PMID: 24278323
The actin-associated protein Pdlim7 is essential for heart and fin development in zebrafish; however, the expression and function of this PDZ-LIM family member in the mammal has remained unclear. Here,...
10.
Mavroudis C, Fitchev P, Plunkett B, Crawford S
World J Pediatr Congenit Heart Surg
. 2013 Jun;
1(1):137-9.
PMID: 23804735
Patency of the ductus arteriosus is critical in maintaining fetal circulation, and premature closure is associated with fetal and early neonatal death. We present 2 cases of sudden demise in...