Philip C Trackman
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Explore the profile of Philip C Trackman including associated specialties, affiliations and a list of published articles.
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70
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1920
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Recent Articles
1.
Karagianni A, Karkempetzaki A, Brooks D, Matsuura S, Dambal V, Trackman P, et al.
Blood
. 2024 Apr;
143(25):2666-2670.
PMID: 38635757
Lysyl oxidase (LOX) is a facilitator of extracellular matrix cross-linking. Using newly developed megakaryocyte-specific LOX knockout mice, we show that LOX expressed in these scarce bone marrow cells affects bone...
2.
Peymanfar Y, Mahjour F, Shrestha N, de la Cueva A, Chen Y, Huang S, et al.
Int J Mol Sci
. 2023 Jun;
24(11).
PMID: 37298359
Oral cancer is primarily squamous-cell carcinoma with a 5-year survival rate of approximately 50%. Lysyl oxidase (LOX) participates in collagen and elastin maturation. The propeptide of LOX is released as...
3.
Trackman P
Int J Mol Sci
. 2023 Apr;
24(7).
PMID: 37047014
This Special Issue on lysyl oxidases, which are proteins derived from five related genes known as , and -, brings together articles that reflect some of the diverse approaches and...
4.
Trackman P, Peymanfar Y, Roy S
Int J Mol Sci
. 2022 May;
23(9).
PMID: 35563478
Lysyl oxidases are multifunctional proteins derived from five lysyl oxidase paralogues and lysyl oxidase-like 1 through lysyl oxidase-like 4 (). All participate in the biosynthesis of and maturation of connective...
5.
Daley E, Trackman P
Bone Rep
. 2021 May;
14:101063.
PMID: 33981809
Osteoblast lysyl oxidase (LOX) is a strongly up-regulated mRNA and protein by the glucose-dependent insulinotropic polypeptide (GIP). LOX is critically required for collagen maturation, and was shown to be dramatically...
6.
Daley E, Divieti Pajevic P, Roy S, Trackman P
JBMR Plus
. 2019 Nov;
3(10):e10212.
PMID: 31687648
Diabetic bone disease is a complication of type I and type II diabetes, both of which are increasing in the United States and elsewhere. Increased hip and foot fracture rates...
7.
Kim D, Lee D, Trackman P, Roy S
Am J Pathol
. 2019 Sep;
189(10):1945-1952.
PMID: 31537300
Diabetic retinopathy (DR) is characterized by apoptotic cell loss in the retinal vasculature. Lysyl oxidase propeptide (LOX-PP), released during LOX processing, has been implicated in promoting apoptosis in various diseased...
8.
Lee V, Halabi C, Broekelmann T, Trackman P, Stitziel N, Mecham R
JCI Insight
. 2019 Jun;
5.
PMID: 31211696
Heterozygous missense mutations in lysyl oxidase (LOX) are associated with thoracic aortic aneurysms and dissections. To assess how LOX mutations modify protein function and lead to aortic disease, we studied...
9.
Mahjour F, Dambal V, Shrestha N, Singh V, Noonan V, Kantarci A, et al.
Oncogenesis
. 2019 May;
8(5):34.
PMID: 31086173
Extracellular lysyl oxidases (LOX and LOXL1-LOXL4) are critical for collagen biosynthesis. LOXL2 is a marker of poor survival in oral squamous cell cancer. We investigated mechanisms by which tumor cell...
10.
de la Cueva A, Emmerling M, Lim S, Yang S, Trackman P, Sonenshein G, et al.
Carcinogenesis
. 2018 Mar;
39(7):921-930.
PMID: 29579155
The propeptide (LOX-PP) domain of the lysyl oxidase proenzyme was shown to inhibit the transformed phenotype of breast, lung and pancreatic cells in culture and the formation of Her2/neu-driven breast...