Philip A Kramer
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Explore the profile of Philip A Kramer including associated specialties, affiliations and a list of published articles.
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39
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1181
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Recent Articles
11.
Kramer P, Coen P, Cawthon P, Distefano G, Cummings S, Goodpaster B, et al.
J Gerontol A Biol Sci Med Sci
. 2023 Dec;
79(4).
PMID: 38150179
The age-related decline in muscle mitochondrial energetics contributes to the loss of mobility in older adults. Women experience a higher prevalence of mobility impairment compared to men, but it is...
12.
Mau T, Barnes H, Blackwell T, Kramer P, Bauer S, Marcinek D, et al.
Geroscience
. 2023 Nov;
46(2):2409-2424.
PMID: 37987886
Background: Phenotypic frailty syndrome identifies older adults at greater risk for adverse health outcomes. Despite the critical role of mitochondria in maintaining cellular function, including energy production, the associations between...
13.
Kramer P, Coen P, Cawthon P, Distefano G, Cummings S, Goodpaster B, et al.
medRxiv
. 2023 Nov;
PMID: 37987007
The age-related decline in muscle mitochondrial energetics contributes to the loss of mobility in older adults. Women experience a higher prevalence of mobility impairment compared to men, but it is...
14.
Duchowny K, Mau T, Diaz-Ramierz L, Lui L, Marcinek D, Toledo F, et al.
medRxiv
. 2023 Nov;
PMID: 37986889
Social stress experienced in childhood is associated with adverse health later in life. Mitochondrial function has been implicated as a mechanism for how stressful life events "get under the skin"...
15.
Brennan A, Coen P, Mau T, Hetherington-Rauth M, Toledo F, Kershaw E, et al.
medRxiv
. 2023 Nov;
PMID: 37986822
Objective: Examine the association of ectopic adipose tissue (AT) with skeletal muscle (SM) mitochondrial bioenergetics in older adults. Methods: Cross-sectional data from 829 older adults ≥70 years was used. Total...
16.
Tranah G, Barnes H, Cawthon P, Coen P, Esser K, Hepple R, et al.
medRxiv
. 2023 Nov;
PMID: 37986804
Gene expression in skeletal muscle of older individuals may reflect compensatory adaptations in response to oxidative damage that preserve tissue integrity and maintain function. Identifying associations between oxidative stress response...
17.
Day N, Kelly S, Lui L, Mansfield T, Gaffrey M, Trejo J, et al.
medRxiv
. 2023 Nov;
PMID: 37986748
Oxidative stress is considered a contributor to declining muscle function and mobility during aging; however, the underlying molecular mechanisms remain poorly described. We hypothesized that greater levels of cysteine (Cys)...
18.
Kramer P, Zamora E, Barnes H, Strotmeyer E, Glynn N, Lane N, et al.
medRxiv
. 2023 Nov;
PMID: 37986742
Background: Falls in the older population are a major public health concern. While many physiological and environmental factors have been associated with fall risk, muscle mitochondrial energetics has not yet...
19.
Mau T, Lui L, Distefano G, Kramer P, Ramos S, Toledo F, et al.
J Gerontol A Biol Sci Med Sci
. 2022 Dec;
78(8):1367-1375.
PMID: 36462195
Background: Mitochondrial energetics are an important property of aging muscle, as generation of energy is pivotal to the execution of muscle contraction. However, its association with functional outcomes, including leg...
20.
Chavez J, Tang X, Campbell M, Reyes G, Kramer P, Stuppard R, et al.
Proc Natl Acad Sci U S A
. 2020 Jun;
117(26):15363-15373.
PMID: 32554501
Mitochondrial dysfunction underlies the etiology of a broad spectrum of diseases including heart disease, cancer, neurodegenerative diseases, and the general aging process. Therapeutics that restore healthy mitochondrial function hold promise...