Philine Wangemann
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Explore the profile of Philine Wangemann including associated specialties, affiliations and a list of published articles.
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58
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2261
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Recent Articles
1.
Jeong J, Kim J, Hong H, Wangemann P, Marcus D, Jung J, et al.
Hear Res
. 2019 Dec;
386:107860.
PMID: 31869657
Purinergic receptors protect the cochlea during high-intensity stimulation by providing a parallel shunt pathway through non-sensory neighboring epithelial cells for cation absorption. So far, there is no direct functional evidence...
2.
Kim M, Kim S, Ryu N, Ma J, Kim Y, Jung J, et al.
Theranostics
. 2019 Nov;
9(24):7184-7199.
PMID: 31695761
: Mutations of that abrogate pendrin, expressed in endolymphatic sac, cochlea and vestibule, are known to cause autosomal recessive sensorineural hearing loss with enlargement of the membranous labyrinth. This is...
3.
Nakanishi H, Kurima K, Pan B, Wangemann P, Fitzgerald T, Geleoc G, et al.
Sci Rep
. 2018 Aug;
8(1):12125.
PMID: 30108230
Mouse Tmc1 and Tmc2 are required for sensory transduction in cochlear and vestibular hair cells. Homozygous Tmc1 mice are deaf, Tmc2 mice have normal hearing, and double homozygous Tmc1; Tmc2...
4.
Kudo T, Wangemann P, Marcus D
BMC Physiol
. 2018 Jan;
18(1):1.
PMID: 29368643
Background: Claudins are major components of tight junctions, which form the paracellular barrier between the cochlear luminal and abluminal fluid compartments that supports the large transepithelial voltage difference and the...
5.
Honda K, Kim S, Kelly M, Burns J, Constance L, Li X, et al.
Elife
. 2017 Oct;
6.
PMID: 28994389
Mutations of are a common cause of hearing loss associated with enlargement of the endolymphatic sac (EES). expression in the developing mouse endolymphatic sac is required for acquisition of normal...
6.
Trepiccione F, Soukaseum C, Baudrie V, Kumai Y, Teulon J, Villoutreix B, et al.
Nephrol Dial Transplant
. 2017 Jan;
32(7):1137-1145.
PMID: 28064162
Background: Pendrin, the chloride/bicarbonate exchanger of β-intercalated cells of the renal connecting tubule and the collecting duct, plays a key role in NaCl reabsorption by the distal nephron. Therefore, pendrin...
7.
Krishnamoorthy G, Reimann K, Wangemann P
BMC Physiol
. 2016 Nov;
16(1):6.
PMID: 27806708
Background: In many vascular smooth muscle cells (SMCs), ryanodine receptor-mediated Ca sparks activate large-conductance Ca-activated K (BK) channels leading to lowered SMC [Ca] and vasodilation. Here we investigated whether Ca...
8.
Miyazaki H, Wangemann P, Marcus D
BMC Physiol
. 2016 Aug;
17(1):1.
PMID: 27515813
Background: Disturbance of acid-base balance in the inner ear is known to be associated with hearing loss in a number of conditions including genetic mutations and pharmacologic interventions. Several previous...
9.
Nishio A, Ito T, Cheng H, Fitzgerald T, Wangemann P, Griffith A
Neuroscience
. 2016 May;
329:74-82.
PMID: 27155149
SLC26A4 mutations cause fluctuating and progressive hearing loss associated with enlargement of the vestibular aqueduct (EVA). SLC26A4 encodes a transmembrane anion exchanger called pendrin expressed in nonsensory epithelial cells of...
10.
Lu J, Aguilar A, Zou B, Bao W, Koldas S, Shi A, et al.
Bioorg Med Chem
. 2015 Jul;
23(17):5985-98.
PMID: 26190460
A class of tetracyclic terpenes was synthesized and evaluated for antagonistic activity of endothelin-1 (ET-1) induced vasoconstriction and inhibitory activity of voltage-activated Ca(2+) channels. Three repeated Robinson annulation reactions were...