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Petra I Lorenzo

Explore the profile of Petra I Lorenzo including associated specialties, affiliations and a list of published articles. Areas
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Articles 28
Citations 361
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Recent Articles
1.
Cobo-Vuilleumier N, Rodriguez-Fernandez S, Lopez-Noriega L, Lorenzo P, Franco J, Lachaud C, et al.
Clin Transl Med . 2024 Dec; 14(12):e70134. PMID: 39702941
Background: The complex aetiology of type 1 diabetes (T1D), characterised by a detrimental cross-talk between the immune system and insulin-producing beta cells, has hindered the development of effective disease-modifying therapies....
2.
Martin-Vazquez E, Cobo-Vuilleumier N, Lopez-Noriega L, Lorenzo P, Gauthier B
Int J Biol Sci . 2023 Sep; 19(13):4157-4165. PMID: 37705740
Prostaglandins are lipid mediators involved in physiological processes, such as constriction or dilation of blood vessels, but also pathophysiological processes, which include inflammation, pain and fever. They are produced by...
3.
Vazquez E, Cobo-Vuilleumier N, Legido R, Marin-Canas S, Nola E, Dorronsoro A, et al.
iScience . 2022 May; 25(5):104345. PMID: 35602948
LRH-1/NR5A2 is implicated in islet morphogenesis postnatally, and its activation using the agonist BL001 protects islets against apoptosis, reverting hyperglycemia in mouse models of Type 1 Diabetes Mellitus. Islet transcriptome...
4.
Gauthier B, Lorenzo P, Comaills V
Cancers (Basel) . 2022 Jan; 14(1). PMID: 35008251
During metastasis, invading tumor cells and circulating tumor cells (CTC) face multiple mechanical challenges during migration through narrow pores and cell squeezing. However, little is known on the importance and...
5.
Lorenzo P, Vazquez E, Lopez-Noriega L, Fuente-Martin E, Mellado-Gil J, Franco J, et al.
Theranostics . 2021 Jun; 11(14):6983-7004. PMID: 34093866
We recently demonstrated that the 'Metabesity' factor HMG20A regulates islet beta-cell functional maturity and adaptation to physiological stress such as pregnancy and pre-diabetes. HMG20A also dictates central nervous system (CNS)...
6.
Lorenzo P, Cobo-Vuilleumier N, Martin-Vazquez E, Lopez-Noriega L, Gauthier B
Int J Mol Sci . 2021 Apr; 22(8). PMID: 33921851
Diabetes is a chronic metabolic disease caused by an absolute or relative deficiency in functional pancreatic β-cells that leads to defective control of blood glucose. Current treatments for diabetes, despite...
7.
Lorenzo P, Martin-Montalvo A, Cobo Vuilleumier N, Gauthier B
Int J Mol Sci . 2019 Dec; 20(24). PMID: 31817798
Gestational diabetes mellitus (GDM), a metabolic disease that develops with the increase in insulin resistance during late pregnancy, is currently one of the most common complications affecting pregnancy. The polygenic...
8.
Cobo-Vuilleumier N, Lorenzo P, Gauthier B
Cell Stress . 2019 Jun; 2(6):141-143. PMID: 31225479
Type 1 diabetes mellitus (T1DM) is defined as an autoimmune disease that targets the selective destruction of islet insulin-producing beta cells by infiltrating immune cells (insulitis). As a result, the...
9.
Fuente-Martin E, Mellado-Gil J, Cobo-Vuilleumier N, Martin-Montalvo A, Romero-Zerbo S, Diaz Contreras I, et al.
Genes (Basel) . 2019 May; 10(5). PMID: 31072002
The high prevalence of type 2 diabetes mellitus (T2DM), together with the fact that current treatments are only palliative and do not avoid major secondary complications, reveals the need for...
10.
Martin-Montalvo A, Lopez-Noriega L, Jimenez-Moreno C, Herranz A, Lorenzo P, Cobo-Vuilleumier N, et al.
Diabetes . 2018 Oct; 68(1):109-118. PMID: 30352879
Transient expression was reported in mouse islets during gestation, whereas a genome-wide linkage and admixture mapping study highlighted as a candidate gene for diabetes mellitus (DM). We sought the significance...