Petr Kosztyu
Overview
Explore the profile of Petr Kosztyu including associated specialties, affiliations and a list of published articles.
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Articles
21
Citations
166
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Recent Articles
1.
Kuchar M, Sloupenska K, Raskova Kafkova L, Groza Y, Skarda J, Kosztyu P, et al.
Cell Commun Signal
. 2024 Oct;
22(1):469.
PMID: 39354587
Background: Human interleukin-22 (IL-22) is known as a "dual function" cytokine that acts as a master regulator to maintain homeostasis, structural integrity of the intestinal epithelial barrier, and shielding against...
2.
Turanek J, Kosztyu P, Knotigova P, Bartheldyova E, Hubatka F, Odehnalova N, et al.
Int J Pharm
. 2024 Jul;
661:124465.
PMID: 39004290
Liposomes are one of the most important drug delivery vectors, nowadays used in clinics. In general, polyethylene glycol (PEG) is used to ensure the stealth properties of the liposomes. Here,...
3.
Groza Y, Lacina L, Kuchar M, Raskova Kafkova L, Zachova K, Janouskova O, et al.
Cell Commun Signal
. 2024 May;
22(1):261.
PMID: 38715108
Background: Interleukin-6 (IL-6) is a multifunctional cytokine that controls the immune response, and its role has been described in the development of autoimmune diseases. Signaling via its cognate IL-6 receptor...
4.
Mierzwicka J, Petrokova H, Raskova Kafkova L, Kosztyu P, cerny J, Kuchar M, et al.
J Transl Med
. 2024 May;
22(1):426.
PMID: 38711085
Background: Programmed cell death 1 (PD-1) belongs to immune checkpoint proteins ensuring negative regulation of the immune response. In non-small cell lung cancer (NSCLC), the sensitivity to treatment with anti-PD-1...
5.
Jemelkova J, Stuchlova Horynova M, Kosztyu P, Zachova K, Zadrazil J, Galuszkova D, et al.
Kidney Int Rep
. 2023 May;
8(5):1068-1075.
PMID: 37180502
Introduction: Immunoglobulin A1 (IgA1) with galactose-deficient -glycans (Gd-IgA1) play a key role in the pathogenesis of IgA nephropathy (IgAN). Mucosal-tissue infections increase IL-6 production and, in patients with IgAN, are...
6.
Daniel Liskova V, Kosztyu P, Kuchar M, cerny J, Bharadwaj S, Petrokova H, et al.
Front Immunol
. 2022 Dec;
13:1066361.
PMID: 36569830
Introduction: Imprinting broadly neutralizing antibody (bNAb) paratopes by shape complementary protein mimotopes represents a potential alternative for developing vaccine immunogens. This approach, designated as a Non-Cognate Ligand Strategy (NCLS), has...
7.
Sova M, Kudelka M, Raska M, Mizera J, Mikulkova Z, Trajerova M, et al.
Viruses
. 2022 Nov;
14(11).
PMID: 36366522
Analysing complex datasets while maintaining the interpretability and explainability of outcomes for clinicians and patients is challenging, not only in viral infections. These datasets often include a variety of heterogeneous...
8.
Zachova K, Jemelkova J, Kosztyu P, Ohyama Y, Takahashi K, Zadrazil J, et al.
J Am Soc Nephrol
. 2022 Feb;
33(5):908-917.
PMID: 35115327
Background: IgA nephropathy (IgAN) primary glomerulonephritis is characterized by the deposition of circulating immune complexes composed of polymeric IgA1 molecules with altered O-glycans (Gd-IgA1) and anti-glycan antibodies in the kidney...
9.
Kuchar M, Kosztyu P, Daniel Liskova V, cerny J, Petrokova H, Vroblova E, et al.
Virulence
. 2021 May;
12(1):1271-1287.
PMID: 33993840
One of the proposed strategies for the development of a more efficient HIV-1 vaccine is based on the identification of proteins binding to a paratope of chosen broadly neutralizing antibody...
10.
Zachova K, Kosztyu P, Zadrazil J, Matousovic K, Vondrak K, Hubacek P, et al.
Front Immunol
. 2020 Mar;
11:267.
PMID: 32184780
IgA nephropathy (IgAN) is the dominant type of primary glomerulonephritis worldwide. However, IgAN rarely affects African Blacks and is uncommon in African Americans. Polymeric IgA1 with galactose-deficient hinge-region glycans is...