Peter Z Qin
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Explore the profile of Peter Z Qin including associated specialties, affiliations and a list of published articles.
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55
Citations
733
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Recent Articles
1.
Allen A, Cooper B, Singh J, Rohs R, Qin P
Sci Rep
. 2025 Feb;
15(1):4930.
PMID: 39929897
Cas12a is a class 2 type V CRISPR-associated nuclease that uses an effector complex comprised of a single protein activated by a CRISPR-encoded small RNA to cleave double-stranded DNA at...
2.
Newsom S, Wang D, Rostami S, Schuster I, Parameshwaran H, Joseph Y, et al.
CRISPR J
. 2023 Dec;
6(6):527-542.
PMID: 38108519
To protect against mobile genetic elements (MGEs), some bacteria and archaea have clustered regularly interspaced short palindromic repeats-CRISPR associated (CRISPR-Cas) adaptive immune systems. CRISPR RNAs (crRNAs) bound to Cas nucleases...
3.
Zhang M, Feng J, Li Y, Qin P, Chai Y
Genesis
. 2023 Dec;
62(1):e23582.
PMID: 38069547
Tfap2b, a pivotal transcription factor, plays critical roles within neural crest cells and their derived lineage. To unravel the intricate lineage dynamics and contribution of these Tfap2b+ cells during craniofacial...
4.
Li Y, Cooper B, Liu Y, Wu D, Zhang X, Rohs R, et al.
Biochemistry
. 2023 Aug;
62(17):2541-2548.
PMID: 37552860
CRISPR-Cas9 has been adapted as a readily programmable genome manipulation agent, and continuing technological advances rely on an in-depth mechanistic understanding of Cas9 target discrimination. Cas9 interrogates a target by...
5.
Singh J, Liu K, Allen A, Jiang W, Qin P
Nucleic Acids Res
. 2023 Jul;
51(16):8730-8743.
PMID: 37522352
CRISPR-associated proteins such as Cas9 and Cas12a are programable RNA-guided nucleases that have emerged as powerful tools for genome manipulation and molecular diagnostics. However, these enzymes are prone to cleaving...
6.
Singh J, Liu K, Allen A, Jiang W, Qin P
bioRxiv
. 2023 Jun;
PMID: 37292754
CRISPR-associated proteins such as Cas9 and Cas12a are programable RNA-guided nucleases that have emerged as powerful tools for genome manipulation and molecular diagnostics. However, these enzymes are prone to cleaving...
7.
Hu Y, Wang Y, Singh J, Sun R, Xu L, Niu X, et al.
ACS Chem Biol
. 2022 Sep;
17(9):2448-2460.
PMID: 36069699
Pulsed electron-electron double resonance (PELDOR) spectroscopy, X-ray scattering interferometry (XSI), and single-molecule Förster resonance energy transfer (smFRET) are molecular rulers that provide inter- or intramolecular pair-wise distance distributions in the...
8.
Li Y, Liu Y, Singh J, Tangprasertchai N, Trivedi R, Fang Y, et al.
CRISPR J
. 2022 Mar;
5(2):341-352.
PMID: 35352981
CRISPR-Cas9 is an RNA-guided nuclease that has been widely adapted for genome engineering. A key determinant in Cas9 target selection is DNA duplex unwinding to form an R-loop, in which...
9.
Babu K, Kathiresan V, Kumari P, Newsom S, Parameshwaran H, Chen X, et al.
Biochemistry
. 2021 Nov;
60(49):3783-3800.
PMID: 34757726
CRISPR-Cas systems are RNA-guided nucleases that provide adaptive immune protection in bacteria and archaea against intruding genomic materials. Cas9, a type-II CRISPR effector protein, is widely used for gene editing...
10.
Parameshwaran H, Babu K, Tran C, Guan K, Allen A, Kathiresan V, et al.
FEBS Lett
. 2021 Feb;
595(7):892-912.
PMID: 33523494
Cas12a is an RNA-guided DNA endonuclease of the type V-A CRISPR-Cas system that has evolved convergently with the type II Cas9 protein. We previously showed that proline substitutions in the...