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Peter W Jurutka

Explore the profile of Peter W Jurutka including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 82
Citations 2120
Followers 0
Related Specialties
Biochemistry
Oncology
Molecular Biology
Top 10 Co-Authors
Mark R Haussler
G Kerr Whitfield
Carl E Wagner
Pamela A Marshall
Ichiro Kaneko
Elizabeth T Jacobs
Carol A Haussler
Jui-Cheng Hsieh
Marya S Sabir
Elizabeth A Hibler
Published In
Biochem Biophys Res Commun
J Med Chem
Cancer Epidemiol Biomarkers Prev
J Steroid Biochem Mol Biol
Cancer Prev Res (Phila)
Affiliations
Soon will be listed here.
Recent Articles
1.
Modeling, synthesis and cell-based evaluation of pyridine-substituted analogs of CD3254 and fluorinated analogs of CBt-PMN as novel therapeutics
Jurutka P, Khan Z, Kaneko I, Sausedo M, Shahani P, MacNeill M, et al.
Bioorg Med Chem . 2025 Jan; 119:118059. PMID: 39808894
Six pyridine analogs of (E)-3-(3-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)-4-hydroxyphenyl)acrylic acid-or CD3254 (11)-in addition to two novel analogs of 1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-1H-benzo[d][1,2,3]triazole-5-carboxylic acid (CBt-PMN or 23) were prepared and evaluated for selective retinoid-X-receptor (RXR) agonism alongside bexarotene...
2.
Synergistic Activation of VDR-RXR Heterodimers by Vitamin D and Rexinoids in Human Kidney and Brain Cells
Doost M, Hong J, Broatch J, Applegate M, Wagner C, Marshall P, et al.
Cells . 2024 Nov; 13(22). PMID: 39594626
The active form of vitamin D, 1,25-dihydroxyvitamin D (1,25D), binds to the vitamin D receptor (VDR) with high affinity. The VDR then heterodimerizes with the retinoid X receptor (RXR) and...
3.
Rexinoids Induce Differential Gene Expression in Human Glioblastoma Cells and Protein-Protein Interactions in a Yeast Two-Hybrid System
Hackney J, Broatch J, Dallal R, Brotherson C, Livingston S, Sabir Z, et al.
ACS Chem Neurosci . 2024 Jul; 15(15):2897-2915. PMID: 39012782
Rexinoids are compounds that bind to the rexinoid X receptor (RXR) to modulate gene expression and have been proposed as a new class of therapeutics to treat Alzheimer's disease. Different...
4.
The Role of Intestinal Cytochrome P450s in Vitamin D Metabolism
Uga M, Kaneko I, Shiozaki Y, Koike M, Tsugawa N, Jurutka P, et al.
Biomolecules . 2024 Jun; 14(6). PMID: 38927120
Vitamin D hydroxylation in the liver/kidney results in conversion to its physiologically active form of 1,25-dihydroxyvitamin D [1,25(OH)D]. 1,25(OH)D controls gene expression through the nuclear vitamin D receptor (VDR) mainly...
5.
Development of Bexarotene Analogs for Treating Cutaneous T-Cell Lymphomas
Warda A, Staniszewski L, Sabir Z, Livingston S, Sausedo M, Reshi S, et al.
Cells . 2023 Nov; 12(21). PMID: 37947652
Bexarotene, a drug approved for treatment of cutaneous T-cell lymphoma (CTCL), is classified as a rexinoid by its ability to act as a retinoid X receptor (RXR) agonist with high...
6.
Dietary GG extracellular vesicles enhance antiprogrammed cell death 1 (anti-PD-1) immunotherapy efficacy against colorectal cancer
Lu S, Xu J, Zhao Z, Guo Y, Zhang H, Jurutka P, et al.
Food Funct . 2023 Nov; 14(23):10314-10328. PMID: 37916395
There is a need to explore combination therapy to improve the efficacy of immunotherapy for colorectal cancer through food probiotics. In this study, extracellular vesicles (EV) derived from GG (LGG-EV)...
7.
Genomically anchored vitamin D receptor mediates an abundance of bioprotective actions elicited by its 1,25-dihydroxyvitamin D hormonal ligand
Haussler M, Haussler C, Jurutka P
Vitam Horm . 2023 Sep; 123:313-383. PMID: 37717990
The nuclear vitamin D receptor (VDR) mediates the actions of its physiologic 1,25-dihydroxyvitamin D (1,25D) ligand produced in kidney and at extrarenal sites during times of physiologic and cellular stress....
8.
Vitamin D Receptor Antagonist MeTC7 Inhibits PD-L1
Khazan N, Quarato E, Singh N, Snyder C, Moore T, Miller J, et al.
Cancers (Basel) . 2023 Jul; 15(13). PMID: 37444542
Small-molecule inhibitors of PD-L1 are postulated to control immune evasion in tumors similar to antibodies that target the PD-L1/PD-1 immune checkpoint axis. However, the identity of targetable PD-L1 inducers is...
9.
Prediagnostic 25-Hydroxyvitamin D in Association with Cancer-specific and All-cause Mortality among Low-income, Non-Hispanic Black Americans with Colorectal Cancer
Lawler T, Khankari N, Shu X, Steinwandel M, Cai Q, Jurutka P, et al.
Cancer Epidemiol Biomarkers Prev . 2023 May; 32(8):1061-1068. PMID: 37257199
Background: Observational studies show high prediagnosis 25-hydroxyvitamin D is associated with lower mortality after colorectal cancer diagnosis. Results from clinical trials suggest vitamin D supplementation may improve outcomes among patients...
10.
An Isochroman Analog of CD3254 and Allyl-, Isochroman-Analogs of NEt-TMN Prove to Be More Potent Retinoid-X-Receptor (RXR) Selective Agonists Than Bexarotene
Jurutka P, Di Martino O, Reshi S, Mallick S, Sausedo M, Moen G, et al.
Int J Mol Sci . 2022 Dec; 23(24). PMID: 36555852
Bexarotene is an FDA-approved drug for the treatment of cutaneous T-cell lymphoma (CTCL); however, its use provokes or disrupts other retinoid-X-receptor (RXR)-dependent nuclear receptor pathways and thereby incites side effects...