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» Authors » Peter T E Wootton

Peter T E Wootton

Explore the profile of Peter T E Wootton including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 117
Followers 0
Related Specialties
Molecular Biology
Genetics
Cardiology & Vascular Diseases
Top 10 Co-Authors
Steve E Humphries
Hugh E Montgomery
Philippa J Talmud
John R Payne
Sukhbir S Dhamrait
Emma Hawe
Ping Li
Jeffrey W Stephens
Alun Jones
David M Flavell
Published In
Hum Mol Genet
Hypertension
Eur Heart J
J Mol Med (Berl)
J Appl Physiol (1985)
Affiliations
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Recent Articles
1.
Tagging SNP haplotype analysis of the secretory PLA2-V gene, PLA2G5, shows strong association with LDL and oxLDL levels, suggesting functional distinction from sPLA2-IIA: results from the UDACS study
Wootton P, Arora N, Drenos F, Thompson S, Cooper J, Stephens J, et al.
Hum Mol Genet . 2007 Jun; 16(12):1437-44. PMID: 17545304
Animal and human studies suggest that both secretory PLA2 (sPLA2)-V and sPLA2-IIA (encoded, respectively, by the neighbouring PLA2G5 and PLA2G2A genes) contribute to atherogenesis. Elevated plasma sPLA2-IIA predicts coronary heart...
2.
Lipoprotein-associated phospholipase A2 A379V variant is associated with body composition changes in response to exercise training
Wootton P, Flavell D, Montgomery H, World M, Humphries S, Talmud P
Nutr Metab Cardiovasc Dis . 2006 Dec; 17(1):24-31. PMID: 17174223
Lipoprotein-associated PLA2 (Lp-PLA2) hydrolyses the sn-2 position of glycerophospholipids, in particular platelet activating factor (PAF), generating significant amounts of Lyso-PAF which in turn, via a remodelling pathway, can generate arachidonic...
3.
Variation in the lipoprotein lipase gene influences exercise-induced left ventricular growth
Flavell D, Wootton P, Myerson S, J World M, Pennell D, Humphries S, et al.
J Mol Med (Berl) . 2006 Jan; 84(2):126-31. PMID: 16416313
The adult heart relies predominantly on fatty acids (FA) for energy generation, and defects in FA catabolism cause dramatic left ventricular (LV) growth in early age. Since lipoprotein lipase (LPL)...
4.
Tagging-SNP haplotype analysis of the secretory PLA2IIa gene PLA2G2A shows strong association with serum levels of sPLA2IIa: results from the UDACS study
Wootton P, Drenos F, Cooper J, Thompson S, Stephens J, Hurt-Camejo E, et al.
Hum Mol Genet . 2005 Dec; 15(2):355-61. PMID: 16368710
Recent prospective analysis identified secretory phospholipase A(2)-IIa (sPLA(2)IIa) as a coronary artery disease (CAD) risk predictor. This study aimed to examine the relationship between serum levels of sPLA(2)IIa and variation...
5.
Bradykinin receptor gene variant and human physical performance
Williams A, Dhamrait S, Wootton P, Day S, Hawe E, Payne J, et al.
J Appl Physiol (1985) . 2003 Nov; 96(3):938-42. PMID: 14607851
Accumulating evidence suggests that athletic performance is strongly influenced by genetic variation. One such locus of influence is the gene for angiotensin-I converting enzyme (ACE), which exhibits a common variant...
6.
Variation in bradykinin receptor genes increases the cardiovascular risk associated with hypertension
Dhamrait S, Payne J, Li P, Jones A, Toor I, Cooper J, et al.
Eur Heart J . 2003 Sep; 24(18):1672-80. PMID: 14499231
Aims: The contribution of kinins to the beneficial effects of angiotensin I converting enzyme (ACE) inhibition in cardiovascular risk reduction remains unclear. The genes for the kinin inducible B1 receptor...
7.
Genetic variants of angiotensin II receptors and cardiovascular risk in hypertension
Jones A, Dhamrait S, Payne J, Hawe E, Li P, Toor I, et al.
Hypertension . 2003 Aug; 42(4):500-6. PMID: 12925562
Renin-angiotensin systems may mediate cardiovascular disease pathogenesis through a balance of actions of angiotensin II on (potentially proatherogenic) constitutive type 1 (AT1R) and (potentially antiatherogenic) inducible type 2 (AT2R) receptors....