David M Flavell
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Explore the profile of David M Flavell including associated specialties, affiliations and a list of published articles.
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16
Citations
407
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Recent Articles
1.
Falcetti E, Flavell D, Staels B, Tinker A, Haworth S, Clapp L
Biochem Biophys Res Commun
. 2007 Jul;
360(4):821-7.
PMID: 17624303
Stable prostacyclin analogues can signal through cell surface IP receptors or by ligand binding to nuclear peroxisome proliferator-activated receptors (PPARs). So far these agents have been reported to activate PPARalpha...
2.
Talmud P, Flavell D, AlFakih K, Cooper J, Balmforth A, Sivananthan M, et al.
Clin Sci (Lond)
. 2007 Feb;
112(12):617-24.
PMID: 17291198
LVH [LV (left ventricular) hypertrophy] is an independent risk factor for CHD (coronary heart disease). During LVH, the preferred cardiac energy substrate switches from FAs (fatty acids) to glucose. LPL...
3.
Wootton P, Flavell D, Montgomery H, World M, Humphries S, Talmud P
Nutr Metab Cardiovasc Dis
. 2006 Dec;
17(1):24-31.
PMID: 17174223
Lipoprotein-associated PLA2 (Lp-PLA2) hydrolyses the sn-2 position of glycerophospholipids, in particular platelet activating factor (PAF), generating significant amounts of Lyso-PAF which in turn, via a remodelling pathway, can generate arachidonic...
4.
Ahmetov I, Mozhayskaya I, Flavell D, Astratenkova I, Komkova A, Lyubaeva E, et al.
Eur J Appl Physiol
. 2006 Mar;
97(1):103-8.
PMID: 16506057
Peroxisome proliferator-activated receptor alpha (PPARalpha) regulates genes responsible for skeletal and heart muscle fatty acid oxidation. Previous studies have shown that the PPARalpha intron 7 G/C polymorphism was associated with...
5.
Flavell D, Wootton P, Myerson S, J World M, Pennell D, Humphries S, et al.
J Mol Med (Berl)
. 2006 Jan;
84(2):126-31.
PMID: 16416313
The adult heart relies predominantly on fatty acids (FA) for energy generation, and defects in FA catabolism cause dramatic left ventricular (LV) growth in early age. Since lipoprotein lipase (LPL)...
6.
Flavell D, Ireland H, Stephens J, Hawe E, Acharya J, Mather H, et al.
Diabetes
. 2005 Jan;
54(2):582-6.
PMID: 15677519
Dysregulation of fatty acid metabolism is important in the pathogenesis of type 2 diabetes. Peroxisome proliferator-activated receptor (PPAR)alpha is a master regulator of fatty acid catabolism, and PPARalpha activators delay...
7.
Foucher C, Rattier S, Flavell D, Talmud P, Humphries S, Kastelein J, et al.
Pharmacogenetics
. 2004 Dec;
14(12):823-9.
PMID: 15608561
Objective: The association between polymorphisms in candidate genes related to lipoprotein metabolism and the reduction in plasma triglyceride (TG) in response to fenofibrate treatment was evaluated in subjects with type...
8.
Putt W, Palmen J, Nicaud V, Tregouet D, Tahri-Daizadeh N, Flavell D, et al.
Hum Mol Genet
. 2004 Jun;
13(15):1587-97.
PMID: 15175273
Upstream stimulatory factor 1 (USF 1), is a transcription factor controlling expression of several genes involved in lipid and glucose homeostasis and co-localizes with familial combined hyperlipidemia (FCHL) and type...
9.
Wells S, Flavell D, Bisset G, Houston P, Christian H, Fairhall K, et al.
J Physiol
. 2003 Jun;
551(Pt 1):323-36.
PMID: 12813157
Human growth hormone (hGH) and bovine neurophysin (bNP) DNA reporter fragments were inserted into the rat vasopressin (VP) and oxytocin (OT) genes in a 44 kb cosmid construct used to...
10.
Elrayess M, Webb K, Flavell D, Syvanne M, Taskinen M, Frick M, et al.
Atherosclerosis
. 2003 May;
168(1):131-8.
PMID: 12732396
A 53G>A polymorphism identified in the 5' untranslated region (5'UTR) of the platelet endothelial cell adhesion molecule-1 (PECAM-1) gene alters a putative shear stress responsive element (SSRE). PECAM-1 was shown...