Peter Steinberger
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Explore the profile of Peter Steinberger including associated specialties, affiliations and a list of published articles.
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128
Citations
2601
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Recent Articles
11.
Arifin M, Leitner J, Egan D, Waidhofer-Sollner P, Kolch W, Zhernovkov V, et al.
iScience
. 2024 Jul;
27(7):110253.
PMID: 39021788
T cell co-inhibitory immune checkpoints, such as PD-1 or BTLA, are bona fide targets in cancer therapy. We used a human T cell reporter line to measure transcriptomic changes mediated...
12.
Santos R, de Sousa Linhares A, Steinberger P, Davis S, Oliveira L, Carmo A
Cell Commun Signal
. 2024 May;
22(1):286.
PMID: 38790044
Background: T-cell membrane scaffold proteins are pivotal in T cell function, acting as versatile signaling hubs. While CD6 forms a large intracellular signalosome, it is distinguished from typical scaffolds like...
13.
Brunnberg J, Barends M, Fruhschulz S, Winter C, Battin C, de Wet B, et al.
Proc Natl Acad Sci U S A
. 2024 May;
121(22):e2321600121.
PMID: 38771881
Antigen presentation via major histocompatibility complex class I (MHC-I) molecules is essential for surveillance by the adaptive immune system. Central to this process is the peptide-loading complex (PLC), which translocates...
14.
Lopez-Cerda S, Molinaro G, Pareja Tello R, Correia A, Kunig S, Steinberger P, et al.
ACS Appl Mater Interfaces
. 2024 Apr;
16(15):18643-18657.
PMID: 38564504
Musculoskeletal diseases involving tissue injury comprise tendon, ligament, and muscle injury. Recently, macrophages have been identified as key players in the tendon repair process, but no therapeutic strategy involving dual...
15.
de Sousa Linhares A, Sharma S, Steinberger P, Leitner J
iScience
. 2024 Mar;
27(3):109267.
PMID: 38455974
Costimulatory signals provided to T cells during antigen encounter have a decisive role in the outcome of immune responses. Here, we used chimeric receptors harboring the extracellular domain of mouse...
16.
Voogd L, Drittij A, Dingenouts C, Franken K, van Unen V, van Meijgaarden K, et al.
iScience
. 2024 Mar;
27(3):109233.
PMID: 38439958
HLA-E molecules can present self- and pathogen-derived peptides to both natural killer (NK) cells and T cells. T cells that recognize HLA-E peptides via their T cell receptor (TCR) are...
17.
Russo V, Prencipe G, Mauro A, El Khatib M, Haidar-Montes A, Cambise N, et al.
Mater Today Bio
. 2024 Feb;
25:101001.
PMID: 38420144
Tendon diseases pose a significant challenge in regenerative medicine due to the limited healing capacity of this tissue. Successful tendon regeneration requires a combination of angiogenesis, immune response, and tenogenesis...
18.
Funk M, Heller G, Waidhofer-Sollner P, Leitner J, Steinberger P
Mol Ther
. 2024 Feb;
32(4):982-999.
PMID: 38384128
Chimeric antigen receptors (CARs) equipped with an inhibitory signaling domain (iCARs) have been proposed as strategy to increase on-tumor specificity of CAR-T cell therapies. iCARs inhibit T cell activation upon...
19.
Bojko M, Wegrzyn K, Sikorska E, Ciura P, Battin C, Steinberger P, et al.
Transl Oncol
. 2024 Feb;
42:101892.
PMID: 38359715
The PD-1/PD-L1 complex belongs to the group of inhibitory immune checkpoints and plays a critical role in immune regulation. The PD-1/PD-L1 axis is also responsible for immune evasion of cancer...
20.
Lippert A, Paluch C, Gaglioni M, Vuong M, McColl J, Jenkins E, et al.
Immunity
. 2024 Feb;
57(2):256-270.e10.
PMID: 38354703
Antibodies can block immune receptor engagement or trigger the receptor machinery to initiate signaling. We hypothesized that antibody agonists trigger signaling by sterically excluding large receptor-type protein tyrosine phosphatases (RPTPs)...