Peter S McPherson
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Explore the profile of Peter S McPherson including associated specialties, affiliations and a list of published articles.
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126
Citations
4384
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Recent Articles
1.
Gonzalez Bolivar S, Ayoubi R, Alende C, Fothouhi M, Shlaifer I, McPherson P, et al.
F1000Res
. 2025 Feb;
13:1559.
PMID: 39916983
VAPB is an adaptor protein known for its role as an anchor for other proteins at the endoplasmic reticulum. A mutant form of VAPB has been linked to amyotrophic lateral...
2.
Ayoubi R, Ryan J, Gonzalez Bolivar S, Alende C, Ruiz Moleon V, Fotouhi M, et al.
Nat Protoc
. 2024 Dec;
PMID: 39690206
Antibody-based research applications are critical for biological discovery. Yet there are no industry standards for comparing the performance of antibodies in various applications. We describe a knockout cell line-based antibody...
3.
Bayati A, Ayoubi R, Aguila A, Zorca C, Deyab G, Han C, et al.
Nat Neurosci
. 2024 Oct;
27(12):2401-2416.
PMID: 39379564
Lewy bodies (LBs), α-synuclein-enriched intracellular inclusions, are a hallmark of Parkinson's disease (PD) pathology, yet a cellular model for LB formation remains elusive. Recent evidence indicates that immune dysfunction may...
4.
Bayati A, McPherson P
J Biol Chem
. 2024 Sep;
300(10):107742.
PMID: 39233232
Research into the pathophysiology of Parkinson's disease (PD) is a fast-paced pursuit, with new findings about PD and other synucleinopathies being made each year. The involvement of various lysosomal proteins,...
5.
Banks E, Francis V, Lin S, Kharfallah F, Fonov V, Levesque M, et al.
Nat Commun
. 2024 Aug;
15(1):7239.
PMID: 39174524
Developmental and epileptic encephalopathies (DEEs) feature altered brain development, developmental delay and seizures, with seizures exacerbating developmental delay. Here we identify a cohort with biallelic variants in DENND5A, encoding a...
6.
Ayoubi R, Alshafie W, Shlaifer I, Southern K, McPherson P, Laflamme C
F1000Res
. 2024 Jul;
12:324.
PMID: 39006307
Sequestosome-1, encoded by the gene , functions as a bridge between ubiquitinated proteins and the proteasome or autophagosome, thereby regulating protein degradation pathways. Loss of Sequestosome-1 is hypothesized to enhance...
7.
Fotouhi M, Worrall D, Ayoubi R, Southern K, McPherson P, Laflamme C
F1000Res
. 2024 Apr;
12:745.
PMID: 38638178
A member of the RNA-binding protein family, T-cell intracellular antigen-1 (TIA1) regulates mRNA translation and splicing as well as cellular stress by promoting stress granule formation. Variants of the gene...
8.
Ruiz Moleon V, Alende C, Fotouhi M, Ayoubi R, Gonzalez Bolivar S, Southern K, et al.
F1000Res
. 2024 Apr;
12:1578.
PMID: 38559361
Rab1 is a highly conserved small GTPase that exists in humans as two isoforms: Rab1A and Rab1B, sharing 92% sequence identity. These proteins regulate vesicle trafficking between the endoplasmic reticulum...
9.
Ayoubi R, Fotouhi M, Southern K, McPherson P, Laflamme C
F1000Res
. 2024 Mar;
12:452.
PMID: 38434631
Vacuolar protein sorting-associated protein 35 is a subunit of the retromer complex, a vital constituent of the endosomal protein sorting pathway. The D620N mutation in the gene has been reported...
10.
Aguila A, Salah S, Kulasekaran G, Shweiki M, Shaul-Lotan N, Mor-Shaked H, et al.
J Biol Chem
. 2024 Mar;
300(4):107124.
PMID: 38432637
Rab35 (Ras-associated binding protein) is a small GTPase that regulates endosomal membrane trafficking and functions in cell polarity, cytokinesis, and growth factor signaling. Altered Rab35 function contributes to progression of...