Peter S Cunningham
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Explore the profile of Peter S Cunningham including associated specialties, affiliations and a list of published articles.
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12
Citations
270
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Recent Articles
1.
Cunningham P, Jackson C, Chakraborty A, Cain J, Durrington H, Blaikley J
Clin Sci (Lond)
. 2023 Jun;
137(11):895-912.
PMID: 37314017
Circadian regulation causes the activity of biological processes to vary over a 24-h cycle. The pathological effects of this variation are predominantly studied using two different approaches: pre-clinical models or...
2.
Jackson C, Stewart I, Plekhanova T, Cunningham P, Hazel A, Al-Sheklly B, et al.
Lancet Respir Med
. 2023 Apr;
11(8):673-684.
PMID: 37072018
Background: Sleep disturbance is common following hospital admission both for COVID-19 and other causes. The clinical associations of this for recovery after hospital admission are poorly understood despite sleep disturbance...
3.
Cunningham P, Kitchen G, Jackson C, Papachristos S, Springthorpe T, van Dellen D, et al.
J Clin Invest
. 2022 Dec;
133(4).
PMID: 36538377
BackgroundAssessing circadian rhythmicity from infrequently sampled data is challenging; however, these types of data are often encountered when measuring circadian transcripts in hospitalized patients.MethodsWe present ClinCirc. This method combines 2...
4.
Hunter A, Pelekanou C, Barron N, Northeast R, Grudzien M, Adamson A, et al.
Elife
. 2021 Aug;
10.
PMID: 34350828
The circadian clock component NR1D1 (REVERBα) is considered a dominant regulator of lipid metabolism, with global deletion driving dysregulation of white adipose tissue (WAT) lipogenesis and obesity. However, a similar...
5.
Hunter A, Pelekanou C, Adamson A, Downton P, Barron N, Cornfield T, et al.
Proc Natl Acad Sci U S A
. 2020 Sep;
117(41):25869-25879.
PMID: 32989157
The nuclear receptor REVERBα is a core component of the circadian clock and proposed to be a dominant regulator of hepatic lipid metabolism. Using antibody-independent ChIP-sequencing of REVERBα in mouse...
6.
Timekeeping in the hindbrain: a multi-oscillatory circadian centre in the mouse dorsal vagal complex
Chrobok L, Northeast R, Myung J, Cunningham P, Petit C, Piggins H
Commun Biol
. 2020 May;
3(1):225.
PMID: 32385329
Metabolic and cardiovascular processes controlled by the hindbrain exhibit 24 h rhythms, but the extent to which the hindbrain possesses endogenous circadian timekeeping is unresolved. Here we provide compelling evidence...
7.
Kitchen G, Cunningham P, Poolman T, Iqbal M, Maidstone R, Baxter M, et al.
Proc Natl Acad Sci U S A
. 2020 Jan;
117(3):1543-1551.
PMID: 31900362
The circadian clock regulates many aspects of immunity. Bacterial infections are affected by time of day, but the mechanisms involved remain undefined. Here we show that loss of the core...
8.
Cunningham P, Meijer P, Nazgiewicz A, Anderson S, Borthwick L, Bagnall J, et al.
Proc Natl Acad Sci U S A
. 2019 Dec;
117(2):1139-1147.
PMID: 31879343
Pulmonary inflammatory responses lie under circadian control; however, the importance of circadian mechanisms in the underlying fibrotic phenotype is not understood. Here, we identify a striking change to these mechanisms...
9.
Cunningham P, Maidstone R, Durrington H, Venkateswaran R, Cypel M, Keshavjee S, et al.
Thorax
. 2018 Oct;
74(4):413-416.
PMID: 30301818
The importance of circadian factors in managing patients is poorly understood. We present two retrospective cohort studies showing that lungs reperfused between 4 and 8 AM have a higher incidence...
10.
Cunningham P, Ahern S, Smith L, da Silva Santos C, Wager T, Bechtold D
Sci Rep
. 2016 Jul;
6:29983.
PMID: 27439882
Growing evidence indicates that disruption of our internal timing system contributes to the incidence and severity of metabolic diseases, including obesity and type 2 diabetes. This is perhaps not surprising...