Peter McErlean
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Explore the profile of Peter McErlean including associated specialties, affiliations and a list of published articles.
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11
Citations
676
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Recent Articles
1.
McErlean P, Bell C, Hewitt R, Busharat Z, Ogger P, Ghai P, et al.
Am J Respir Crit Care Med
. 2021 Jul;
204(8):954-966.
PMID: 34280322
Airway macrophages (AMs) are key regulators of the lung environment and are implicated in the pathogenesis of idiopathic pulmonary fibrosis (IPF), a fatal respiratory disease with no cure. However, knowledge...
2.
McErlean P, Kelly A, Dhariwal J, Kirtland M, Watson J, Ranz I, et al.
Front Genet
. 2020 Dec;
11:585746.
PMID: 33362848
Background: Asthma is a chronic airway disease driven by complex genetic-environmental interactions. The role of epigenetic modifications in bronchial epithelial cells (BECs) in asthma is poorly understood. Methods: We piloted...
3.
Ogger P, Albers G, Hewitt R, OSullivan B, Powell J, Calamita E, et al.
Sci Immunol
. 2020 Oct;
5(52).
PMID: 33097591
Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease in which airway macrophages (AMs) play a key role. Itaconate has emerged as a mediator of macrophage function, but its role...
4.
Allden S, Ogger P, Ghai P, McErlean P, Hewitt R, Toshner R, et al.
Am J Respir Crit Care Med
. 2019 May;
200(2):209-219.
PMID: 31051082
Idiopathic pulmonary fibrosis (IPF) is a devastating progressive disease with limited therapeutic options. Airway macrophages (AMs) are key components of the defense of the airways and are implicated in the...
5.
Correia L, Johnson J, McErlean P, Bauer J, Farah H, Rassl D, et al.
Am J Respir Crit Care Med
. 2017 Feb;
195(11):1494-1508.
PMID: 28199128
Rationale: Improving the early detection and chemoprevention of lung cancer are key to improving outcomes. The pathobiology of early squamous lung cancer is poorly understood. We have shown that amplification...
6.
McErlean P, Favoreto Jr S, Costa F, Shen J, Quraishi J, Biyasheva A, et al.
BMC Med Genomics
. 2014 Jun;
7:37.
PMID: 24947756
Background: Mechanisms underlying the development of virus-induced asthma exacerbations remain unclear. To investigate if epigenetic mechanisms could be involved in virus-induced asthma exacerbations, we undertook DNA methylation profiling in asthmatic...
7.
McErlean P, Berdnikovs S, Favoreto Jr S, Shen J, Biyasheva A, Barbeau R, et al.
Genome Med
. 2014 Jan;
6(1):1.
PMID: 24433494
Background: Acute respiratory illness is the leading cause of asthma exacerbations yet the mechanisms underlying this association remain unclear. To address the deficiencies in our understanding of the molecular events...
8.
McErlean P, Greiman A, Favoreto Jr S, Avila P
Immunol Allergy Clin North Am
. 2010 Oct;
30(4):481-95, v.
PMID: 21029933
Asthma exacerbations are precipitated primarily by respiratory virus infection and frequently require immediate medical intervention. Studies of childhood and adult asthma have implicated a wide variety of respiratory viruses in...
9.
McErlean P, Shackelton L, Andrews E, Webster D, Lambert S, Nissen M, et al.
PLoS One
. 2008 Apr;
3(4):e1847.
PMID: 18382652
Background: Human rhinoviruses (HRVs) are the most frequently detected pathogens in acute respiratory tract infections (ARTIs) and yet little is known about the prevalence, recurrence, structure and clinical impact of...
10.
Arden K, McErlean P, Nissen M, Sloots T, Mackay I
J Med Virol
. 2006 Jul;
78(9):1232-40.
PMID: 16847968
Viruses are the major cause of pediatric acute respiratory tract infection (ARTI) and yet many suspected cases of infection remain uncharacterized. We employed 17 PCR assays and retrospectively screened 315...