Peter Lindemann
Overview
Explore the profile of Peter Lindemann including associated specialties, affiliations and a list of published articles.
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Articles
26
Citations
765
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Recent Articles
1.
Fikru S, Tolossa K, Lindemann P, Bucar F, Asres K
J Trop Med
. 2024 Apr;
2024:1051086.
PMID: 38586242
Larvicidal, ovicidal, and repellent activities of the essential oil extracted by hydrodistillation from the leaves of the endemic Ethiopian plant (Hochst. ex Benth.) Briq were investigated against , the dominant...
2.
Yan S, Schope P, Lewis J, Putzker K, Uhrig U, Specker E, et al.
Biomed Pharmacother
. 2023 Oct;
168:115698.
PMID: 37865992
Metastasis is directly linked to poor prognosis of cancer patients and warrants search for effective anti-metastatic drugs. MACC1 is a causal key molecule for metastasis. High MACC1 expression is prognostic...
3.
CLK2 and CLK4 are regulators of DNA damage-induced NF-κB targeted by novel small molecule inhibitors
Mucka P, Lindemann P, Bosco B, Willenbrock M, Radetzki S, Neuenschwander M, et al.
Cell Chem Biol
. 2023 Jul;
30(10):1303-1312.e3.
PMID: 37506701
Transcription factor NF-κB potently activates anti-apoptotic genes, and its inactivation significantly reduces tumor cell survival following genotoxic stresses. We identified two structurally distinct lead compounds that selectively inhibit NF-κB activation...
4.
Fernandez-Bachiller M, Hwang S, Schembri M, Lindemann P, Guberman M, Herziger S, et al.
J Med Chem
. 2022 Sep;
65(19):13013-13028.
PMID: 36178213
The accurate prediction of protein-ligand binding affinity belongs to one of the central goals in computer-based drug design. Molecular dynamics (MD)-based free energy calculations have become increasingly popular in this...
5.
Compound Interaction Screen on a Photoactivatable Cellulose Membrane (CISCM) Identifies Drug Targets
Melder F, Lindemann P, Welle A, Trouillet V, Heissler S, Nazare M, et al.
ChemMedChem
. 2022 Jul;
17(19):e202200346.
PMID: 35867055
Identifying the protein targets of drugs is an important but tedious process. Existing proteomic approaches enable unbiased target identification but lack the throughput needed to screen larger compound libraries. Here,...
6.
Li X, Ru T, Navarro-Vazquez A, Lindemann P, Nazare M, Li X, et al.
J Nat Prod
. 2022 Jul;
85(7):1730-1737.
PMID: 35792821
Natural product dimers have intriguing structural features and often have remarkable pharmacological activities. We report here two uncommon marine gorgonian-derived symmetric dimers, weizhouochrones A () and B (), with indenone-derived...
7.
Barone M, Muller M, Chiha S, Ren J, Albat D, Soicke A, et al.
Proc Natl Acad Sci U S A
. 2020 Nov;
117(47):29684-29690.
PMID: 33184177
Battling metastasis through inhibition of cell motility is considered a promising approach to support cancer therapies. In this context, Ena/VASP-depending signaling pathways, in particular interactions with their EVH1 domains, are...
8.
Alsalim R, Lindemann P, Lopez-Alberca M, Miksche S, Czechtizky W, Halland N, et al.
Org Lett
. 2020 Sep;
22(18):7393-7396.
PMID: 32870012
The development of a novel selective synthesis of 3-amino-2-indazoles from readily available 2-halobenzonitriles is presented. The reaction proceeds through a domino reaction sequence, consisting of a regioselective palladium-catalyzed coupling of...
9.
Schoene J, Gazzi T, Lindemann P, Christmann M, Volkamer A, Nazare M
ChemMedChem
. 2019 Jul;
14(16):1514-1527.
PMID: 31264364
The broader and systematic application of a novel scaffold is often hampered by the unavailability of a short and reliable synthetic access. We investigated a new strategy for the design...
10.
Anumala U, Waaler J, Nkizinkiko Y, Ignatev A, Lazarow K, Lindemann P, et al.
J Med Chem
. 2017 Nov;
60(24):10013-10025.
PMID: 29155568
A structure-guided hybridization approach using two privileged substructures gave instant access to a new series of tankyrase inhibitors. The identified inhibitor 16 displays high target affinity on tankyrase 1 and...