Peter L van Lent
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Explore the profile of Peter L van Lent including associated specialties, affiliations and a list of published articles.
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33
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819
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Recent Articles
1.
CD64 as novel molecular imaging marker for the characterization of synovitis in rheumatoid arthritis
Theeuwes W, Di Ceglie I, Dorst D, Blom A, Bos D, Vogl T, et al.
Arthritis Res Ther
. 2023 Aug;
25(1):158.
PMID: 37653557
Background: Rheumatoid arthritis (RA) is one of the most prevalent and debilitating joint diseases worldwide. RA is characterized by synovial inflammation (synovitis), which is linked to the development of joint...
2.
Aarts J, van Caam A, Chen X, Marijnissen R, Helsen M, Walgreen B, et al.
Sci Rep
. 2022 Feb;
12(1):3182.
PMID: 35210510
TGF-β1 is an important growth factor to promote the differentiation of T helper 17 (Th17) and regulatory T cells (Treg). The potential of TGF-β1 as therapeutic target in T cell-mediated...
3.
Aarts J, Roeleveld D, Helsen M, Walgreen B, Vitters E, Kolls J, et al.
Rheumatology (Oxford)
. 2020 Nov;
60(4):1974-1983.
PMID: 33197269
Objective: High levels of IL-22 are present in serum and synovial fluid of patients with RA. As both pro- and anti-inflammatory roles for IL-22 have been described in studies using...
4.
Blom A, van den Bosch M, Blaney Davidson E, Roth J, Vogl T, van de Loo F, et al.
Arthritis Res Ther
. 2020 Aug;
22(1):199.
PMID: 32854769
Background: Synovitis-associated pain is mediated by inflammatory factors that may include S100A8/9, which is able to stimulate nociceptive neurons via Toll-like receptor 4. In this study, we investigated the role...
5.
Di Ceglie I, Blom A, Davar R, Logie C, Martens J, Habibi E, et al.
FASEB J
. 2019 Jun;
33(9):10104-10115.
PMID: 31199668
The alarmin S100A8/A9 is implicated in sterile inflammation-induced bone resorption and has been shown to increase the bone-resorptive capacity of mature osteoclasts. Here, we investigated the effects of S100A9 on...
6.
Tweehuysen L, den Broeder N, van Herwaarden N, Joosten L, van Lent P, Vogl T, et al.
RMD Open
. 2018 Apr;
4(1):e000654.
PMID: 29657832
Objectives: Calprotectin (S100A8/A9) has been correlated with disease activity in rheumatoid arthritis (RA). The aim of this study was to investigate the predictive value of serum calprotectin for clinical response...
7.
Rogier R, Evans-Marin H, Manasson J, van der Kraan P, Walgreen B, Helsen M, et al.
Sci Rep
. 2017 Nov;
7(1):15613.
PMID: 29142301
Perturbations of the intestinal microbiome have been observed in patients with new-onset and chronic autoimmune inflammatory arthritis. However, it is currently unknown whether these alterations precede the development of arthritis...
8.
van den Akker G, van Beuningen H, Vitters E, Koenders M, van de Loo F, van Lent P, et al.
Cell Signal
. 2017 Sep;
40:190-199.
PMID: 28943409
Background: Chondrogenic differentiation of mesenchymal stem cells (MSC) requires transforming growth factor beta (TGFβ) signaling. TGFβ binds to the type I receptor activin-like kinase (ALK)5 and results in C-terminal SMAD2/3...
9.
van den Bosch M, Blom A, van de Loo F, Koenders M, Lafeber F, van den Berg W, et al.
Arthritis Rheumatol
. 2017 Jul;
69(10):1978-1983.
PMID: 28678406
Objective: Increased Wnt signaling in chondrocytes is associated with development of osteoarthritis (OA). However, OA is considered a disease of the entire joint, where the synovium has been attributed an...
10.
Roeleveld D, Marijnissen R, Walgreen B, Helsen M, van den Bersselaar L, van de Loo F, et al.
PLoS One
. 2017 Feb;
12(2):e0171757.
PMID: 28158305
Th17 cells and their cytokines are linked to the pathogenesis of rheumatoid arthritis, a chronic autoimmune disease characterized by joint inflammation. Th17 development is initiated by combined signaling of TGF-β...