Peter Greb
Overview
Explore the profile of Peter Greb including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
563
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Recent Articles
1.
Vetma V, Perez L, Elias J, Stingu A, Kombara A, Gmaschitz T, et al.
ACS Chem Biol
. 2024 Jul;
19(7):1484-1494.
PMID: 38958654
Targeted protein degradation has recently emerged as a novel option in drug discovery. Natural protein half-life is expected to affect the efficacy of degrading agents, but to what extent it...
2.
Junk L, Schmiedel V, Guha S, Fischel K, Greb P, Vill K, et al.
Nat Commun
. 2024 Mar;
15(1):2005.
PMID: 38443338
Antimicrobial resistance is a global health threat that requires the development of new treatment concepts. These should not only overcome existing resistance but be designed to slow down the emergence...
3.
Kofink C, Trainor N, Mair B, Wohrle S, Wurm M, Mischerikow N, et al.
Nat Commun
. 2022 Oct;
13(1):5969.
PMID: 36216795
Targeted protein degradation offers an alternative modality to classical inhibition and holds the promise of addressing previously undruggable targets to provide novel therapeutic options for patients. Heterobifunctional molecules co-recruit a...
4.
Kessler D, Gollner A, Gmachl M, Mantoulidis A, Martin L, Zoephel A, et al.
Proc Natl Acad Sci U S A
. 2020 Feb;
117(7):3365-3367.
PMID: 32047042
No abstract available.
5.
Kessler D, Gmachl M, Mantoulidis A, Martin L, Zoephel A, Mayer M, et al.
Proc Natl Acad Sci U S A
. 2019 Jul;
116(32):15823-15829.
PMID: 31332011
The 3 human RAS genes, KRAS, NRAS, and HRAS, encode 4 different RAS proteins which belong to the protein family of small GTPases that function as binary molecular switches involved...
6.
Farnaby W, Koegl M, Roy M, Whitworth C, Diers E, Trainor N, et al.
Nat Chem Biol
. 2019 Jul;
15(8):846.
PMID: 31267096
In the version of this article originally published, several lines of text in the last paragraph of the right column on page 1 of the PDF were transposed into the...
7.
Farnaby W, Koegl M, Roy M, Whitworth C, Diers E, Trainor N, et al.
Nat Chem Biol
. 2019 Jun;
15(7):672-680.
PMID: 31178587
Targeting subunits of BAF/PBAF chromatin remodeling complexes has been proposed as an approach to exploit cancer vulnerabilities. Here, we develop proteolysis targeting chimera (PROTAC) degraders of the BAF ATPase subunits...
8.
Popow J, Arnhof H, Bader G, Berger H, Ciulli A, Covini D, et al.
J Med Chem
. 2019 Feb;
62(5):2508-2520.
PMID: 30739444
Focal adhesion tyrosine kinase (PTK2) is often overexpressed in human hepatocellular carcinoma (HCC), and several reports have linked PTK2 depletion and/or pharmacological inhibition to reduced tumorigenicity. However, the clinical relevance...
9.
Kerres N, Steurer S, Schlager S, Bader G, Berger H, Caligiuri M, et al.
Cell Rep
. 2017 Sep;
20(12):2860-2875.
PMID: 28930682
The transcription factor BCL6 is a known driver of oncogenesis in lymphoid malignancies, including diffuse large B cell lymphoma (DLBCL). Disruption of its interaction with transcriptional repressors interferes with the...