Peter E Molloy
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Explore the profile of Peter E Molloy including associated specialties, affiliations and a list of published articles.
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11
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1079
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Recent Articles
1.
Holland C, Crean R, Pentier J, de Wet B, Lloyd A, Srikannathasan V, et al.
J Clin Invest
. 2020 Apr;
130(5):2673-2688.
PMID: 32310221
Tumor-associated peptide-human leukocyte antigen complexes (pHLAs) represent the largest pool of cell surface-expressed cancer-specific epitopes, making them attractive targets for cancer therapies. Soluble bispecific molecules that incorporate an anti-CD3 effector...
2.
Ojiro K, Qu X, Cho H, Park J, Vuidepot A, Lissin N, et al.
J Virol
. 2017 Mar;
91(10).
PMID: 28275182
The antiviral effects of hepatitis C virus (HCV)-specific CD8 T cells have been shown in an HCV replicon system but not in an authentic infectious HCV cell culture (HCVcc) system....
3.
Mansour S, Tocheva A, Cave-Ayland C, Machelett M, Sander B, Lissin N, et al.
Proc Natl Acad Sci U S A
. 2016 Feb;
113(9):E1266-75.
PMID: 26884207
Cluster of differentiation 1c (CD1c)-dependent self-reactive T cells are abundant in human blood, but self-antigens presented by CD1c to the T-cell receptors of these cells are poorly understood. Here we...
4.
Aleksic M, Liddy N, Molloy P, Pumphrey N, Vuidepot A, Chang K, et al.
Eur J Immunol
. 2012 Sep;
42(12):3174-9.
PMID: 22949370
T-cell destiny during thymic selection depends on the affinity of the TCR for autologous peptide ligands presented in the context of MHC molecules. This is a delicately balanced process; robust...
5.
Liddy N, Bossi G, Adams K, Lissina A, Mahon T, Hassan N, et al.
Nat Med
. 2012 May;
18(6):980-7.
PMID: 22561687
T cell immunity can potentially eradicate malignant cells and lead to clinical remission in a minority of patients with cancer. In the majority of these individuals, however, there is a...
6.
Bulek A, Cole D, Skowera A, Dolton G, Gras S, Madura F, et al.
Nat Immunol
. 2012 Jan;
13(3):283-9.
PMID: 22245737
The structural characteristics of the engagement of major histocompatibility complex (MHC) class II-restricted self antigens by autoreactive T cell antigen receptors (TCRs) is established, but how autoimmune TCRs interact with...
7.
Liddy N, Molloy P, Bennett A, Boulter J, Jakobsen B, Li Y
Mol Biotechnol
. 2010 Feb;
45(2):140-9.
PMID: 20143183
Previously, we have described the use of phage display to generate high affinity disulfide bond-linked T cell receptors (TCRs). The affinities of the mutant TCRs were analysed after refolding of...
8.
Varela-Rohena A, Molloy P, Dunn S, Li Y, Suhoski M, Carroll R, et al.
Nat Med
. 2008 Nov;
14(12):1390-5.
PMID: 18997777
HIV's considerable capacity to vary its HLA-I-restricted peptide antigens allows it to escape from host cytotoxic T lymphocytes (CTLs). Nevertheless, therapeutics able to target HLA-I-associated antigens, with specificity for the...
9.
Zhao Y, Bennett A, Zheng Z, Wang Q, Robbins P, Yu L, et al.
J Immunol
. 2007 Oct;
179(9):5845-54.
PMID: 17947658
We examined the activity of human T cells engineered to express variants of a single TCR (1G4) specific for the cancer/testis Ag NY-ESO-1, generated by bacteriophage display with a wide...
10.
Molloy P, Sewell A, Jakobsen B
Curr Opin Pharmacol
. 2005 Jun;
5(4):438-43.
PMID: 15939669
T cell receptors are antigen-specific proteins that have evolved to recognize peptide antigens presented by human leukocyte antigen molecules on most cell types. Like antibodies, T cell receptors are produced...