Peter D Keightley
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Explore the profile of Peter D Keightley including associated specialties, affiliations and a list of published articles.
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94
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5811
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Recent Articles
1.
Lopez-Cortegano E, Chebib J, Jonas A, Vock A, Kunzel S, Keightley P, et al.
Genome Res
. 2024 Dec;
35(1):43-54.
PMID: 39622636
All forms of genetic variation originate from new mutations, making it crucial to understand their rates and mechanisms. Here, we use long-read sequencing from Pacific Biosciences (PacBio) to investigate de...
2.
Chebib J, Jonas A, Lopez-Cortegano E, Kunzel S, Tautz D, Keightley P
PLoS Biol
. 2024 Sep;
22(9):e3002795.
PMID: 39325822
Each generation, spontaneous mutations introduce heritable changes that tend to reduce fitness in populations of highly adapted living organisms. This erosion of fitness is countered by natural selection, which keeps...
3.
Lopez-Cortegano E, Chebib J, Jonas A, Vock A, Kunzel S, Tautz D, et al.
Mol Biol Evol
. 2024 Aug;
41(8).
PMID: 39101589
The mouse serves as a mammalian model for understanding the nature of variation from new mutations, a question that has both evolutionary and medical significance. Previous studies suggest that the...
4.
Wang Y, McNeil P, Abdulazeez R, Pascual M, Johnston S, Keightley P, et al.
Genome Res
. 2023 Apr;
33(4):587-598.
PMID: 37037625
The rates of mutation, recombination, and transposition are core parameters in models of evolution. They impact genetic diversity, responses to ongoing selection, and levels of genetic load. However, even for...
5.
Lopez-Cortegano E, Craig R, Chebib J, Balogun E, Keightley P
Genome Res
. 2023 Jan;
33(1):45-60.
PMID: 36617667
Genetic variation originates from several types of spontaneous mutation, including single-nucleotide substitutions, short insertions and deletions (indels), and larger structural changes. Structural mutations (SMs) drive genome evolution and are thought...
6.
Bondel K, Samuels T, Craig R, Ness R, Colegrave N, Keightley P
PLoS Genet
. 2022 Jun;
18(6):e1009840.
PMID: 35704655
The distribution of fitness effects (DFE) for new mutations is fundamental for many aspects of population and quantitative genetics. In this study, we have inferred the DFE in the single-celled...
7.
Johri P, Aquadro C, Beaumont M, Charlesworth B, Excoffier L, Eyre-Walker A, et al.
PLoS Biol
. 2022 May;
20(5):e3001669.
PMID: 35639797
The field of population genomics has grown rapidly in response to the recent advent of affordable, large-scale sequencing technologies. As opposed to the situation during the majority of the 20th...
8.
9.
Lopez-Cortegano E, Craig R, Chebib J, Samuels T, Morgan A, Kraemer S, et al.
Mol Biol Evol
. 2021 May;
38(9):3709-3723.
PMID: 33950243
De novo mutations are central for evolution, since they provide the raw material for natural selection by regenerating genetic variation. However, studying de novo mutations is challenging and is generally...
10.
Craig R, Hasan A, Ness R, Keightley P
Plant Cell
. 2021 Apr;
33(4):1016-1041.
PMID: 33793842
Despite its role as a reference organism in the plant sciences, the green alga Chlamydomonas reinhardtii entirely lacks genomic resources from closely related species. We present highly contiguous and well-annotated...