Brian Charlesworth
Overview
Explore the profile of Brian Charlesworth including associated specialties, affiliations and a list of published articles.
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Articles
169
Citations
6126
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Recent Articles
1.
Johri P, Charlesworth B
bioRxiv
. 2025 Mar;
PMID: 40027714
A widely used model of the effects of mutations on fitness (the "sites" model) assumes that heterozygous recessive or partially recessive deleterious mutations at different sites in a gene complement...
2.
Bodmer W, Charlesworth B
Am J Hum Genet
. 2025 Jan;
112(1):196-197.
PMID: 39753115
No abstract available.
3.
Charlesworth B, Olito C
Evolution
. 2024 Oct;
78(12):1891-1899.
PMID: 39399984
In their most extreme form, sex chromosomes exhibit a complete lack of genetic recombination along much of their length in the heterogametic sex. Some recent models explain the evolution of...
4.
Charlesworth B
Genetics
. 2023 Dec;
226(3).
PMID: 38147527
Inversions restrict recombination when heterozygous with standard arrangements, but often have few noticeable phenotypic effects. Nevertheless, there are several examples of inversions that can be maintained polymorphic by strong selection...
5.
Berdan E, Barton N, Butlin R, Charlesworth B, Faria R, Fragata I, et al.
J Evol Biol
. 2023 Nov;
36(12):1761-1782.
PMID: 37942504
Inversions are structural mutations that reverse the sequence of a chromosome segment and reduce the effective rate of recombination in the heterozygous state. They play a major role in adaptation,...
6.
Charlesworth B
Genetics
. 2023 Jun;
224(4).
PMID: 37348059
The strong reduction in the frequency of recombination in heterozygotes for an inversion and a standard gene arrangement causes the arrangements to become partially isolated genetically, resulting in sequence divergence...
7.
Charlesworth B, Jensen J
Annu Rev Ecol Evol Syst
. 2023 Apr;
52:177-197.
PMID: 37089401
Patterns of variation and evolution at a given site in a genome can be strongly influenced by the effects of selection at genetically linked sites. In particular, the recombination rates...
8.
Charlesworth B, Jensen J
Mol Biol Evol
. 2022 Dec;
40(2).
PMID: 36572441
It has recently been proposed that lower mutation rates in gene bodies compared with upstream and downstream sequences in Arabidopsis thaliana are the result of an "adaptive" modification of the...
9.
Charlesworth B, Goddard M, Meyer K, Visscher P, Weir B, Wray N
Nat Genet
. 2022 Jul;
54(9):1448.
PMID: 35869320
No abstract available.
10.
Charlesworth B, Goddard M, Meyer K, Visscher P, Weir B, Wray N
Nat Genet
. 2022 Jul;
54(7):934-939.
PMID: 35817969
The quantitative geneticist W. G. ('Bill') Hill, awardee of the 2018 Darwin Medal of the Royal Society and the 2019 Mendel Medal of the Genetics Society (United Kingdom), died on...