Peter Christmas
Overview
Explore the profile of Peter Christmas including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
262
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0
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Recent Articles
1.
Vaivoda R, Vaine C, Boerstler C, Galloway K, Christmas P
J Immunol Res
. 2015 Nov;
2015:250456.
PMID: 26613087
CYP4Fs were first identified as enzymes that catalyze hydroxylation of leukotriene B4 (LTB4). CYP4F18 has an unusual expression in neutrophils and was predicted to play a role in regulating LTB4-dependent...
2.
Christmas P
Adv Pharmacol
. 2015 Aug;
74:163-92.
PMID: 26233907
Cytochrome P450 epoxygenases and hydroxylases play a regulatory role in the activation and suppression of inflammation by generating or metabolizing bioactive mediators. CYP2C and CYP2J epoxygenases convert arachidonic acid to...
3.
Winslow V, Vaivoda R, Vasilyev A, Dombkowski D, Douaidy K, Stark C, et al.
Biochim Biophys Acta
. 2014 Mar;
1841(6):868-79.
PMID: 24632148
Inflammatory responses to infection and injury must be restrained and negatively regulated to minimize damage to host tissue. One proposed mechanism involves enzymatic inactivation of the pro-inflammatory mediator leukotriene B4,...
4.
Soberman R, MacKay C, Vaine C, Ryan G, Cerny A, Thompson M, et al.
PLoS One
. 2012 Oct;
7(10):e47740.
PMID: 23082204
The CD200R1:CD200 axis is traditionally considered to limit tissue inflammation by down-regulating pro-inflammatory signaling in myeloid cells bearing the receptor. We generated CD200R1(-/-) mice and employed them to explore both...
5.
Cooper P, Mesaros A, Zhang J, Christmas P, Stark C, Douaidy K, et al.
PLoS One
. 2010 Apr;
5(4):e10235.
PMID: 20422032
Background: Ozone, a pollutant known to induce airway hyper-responsiveness (AHR), increases morbidity and mortality in patients with obstructive airway diseases and asthma. We postulate oxidized lipids mediate in vivo ozone-induced...
6.
Mandal A, Jones P, Bair A, Christmas P, Miller D, Yamin T, et al.
Proc Natl Acad Sci U S A
. 2008 Dec;
105(51):20434-9.
PMID: 19075240
Leukotrienes (LTs) are signaling molecules derived from arachidonic acid that initiate and amplify innate and adaptive immunity. In turn, how their synthesis is organized on the nuclear envelope of myeloid...
7.
Soberman R, Christmas P
Am J Physiol Lung Cell Mol Physiol
. 2006 Apr;
291(2):L142-3.
PMID: 16581828
No abstract available.
8.
Christmas P, Tolentino K, Primo V, Zemski Berry K, Murphy R, Chen M, et al.
J Biol Chem
. 2005 Dec;
281(11):7189-96.
PMID: 16380383
Leukotriene B(4) (LTB(4)) is a potent chemoattractant for polymorphonuclear leukocytes (PMN) and other cells. Human PMN inactivate LTB(4) by omega-oxidation catalyzed by cytochrome P-450 (CYP) 4F3A. The contribution of the...
9.
Mandal A, Skoch J, Bacskai B, Hyman B, Christmas P, Miller D, et al.
Proc Natl Acad Sci U S A
. 2004 Apr;
101(17):6587-92.
PMID: 15084748
Cell signaling leading to the formation of leukotriene (LT)C(4) requires the localization of the four key biosynthetic enzymes on the outer nuclear membrane and endoplasmic reticulum. Whether any macromolecular organization...
10.
Christmas P, Carlesso N, Shang H, Cheng S, Weber B, Preffer F, et al.
J Biol Chem
. 2003 Apr;
278(27):25133-42.
PMID: 12709424
The cytochrome P450 4F3 (CYP4F3) gene encodes two functionally distinct enzymes that differ only by the selection of exon 4 (CYP4F3A) or exon 3 (CYP4F3B). CYP4F3A inactivates leukotriene B4, a...