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Peter Brodersen

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Articles 51
Citations 4368
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Recent Articles
1.
Bressendorff S, Sjogaard I, Prestel A, Voutsinos V, Jansson M, Menard P, et al.
Nat Struct Mol Biol . 2025 Jan; PMID: 39774835
ARGONAUTE (AGO) proteins bind to small non-coding RNAs to form RNA-induced silencing complexes. In the RNA-bound state, AGO is stable while RNA-free AGO turns over rapidly. Molecular features unique to...
2.
Reichel M, Tankmar M, Rennie S, Arribas-Hernandez L, Lewinski M, Koster T, et al.
EMBO J . 2024 Nov; 43(24):6626-6655. PMID: 39613967
N6-methyladenosine (mA) exerts many of its regulatory effects on eukaryotic mRNAs by recruiting cytoplasmic YT521-B homology-domain family (YTHDF) proteins. Here, we show that in Arabidopsis thaliana, the interaction between mA...
3.
Brodersen P, Arribas-Hernandez L
Curr Opin Plant Biol . 2024 Nov; 82:102650. PMID: 39488190
Plants use mRNA methylation to regulate gene expression. As in other eukaryotes, the only abundant methylated nucleotide in plant mRNA bodies is N6-methyladenosine (mA). The conserved core components of mA-based...
4.
Nielsen C, Arribas-Hernandez L, Han L, Reichel M, Woessmann J, Daucke R, et al.
Plant Cell . 2024 Mar; 36(6):2289-2309. PMID: 38466226
Flowering plant genomes encode four or five DICER-LIKE (DCL) enzymes that produce small interfering RNAs (siRNAs) and microRNAs, which function in RNA interference (RNAi). Different RNAi pathways in plants effect...
5.
Tankmar M, Reichel M, Arribas-Hernandez L, Brodersen P
EMBO Rep . 2023 Nov; 24(12):e57741. PMID: 38009565
N6-methyladenosine (m A) in mRNA is key to eukaryotic gene regulation. Many m A functions involve RNA-binding proteins that recognize m A via a YT521-B Homology (YTH) domain. YTH domain...
6.
Flores-Tellez D, Tankmar M, von Bulow S, Chen J, Lindorff-Larsen K, Brodersen P, et al.
PLoS Genet . 2023 Oct; 19(10):e1010980. PMID: 37816028
YT521-B homology (YTH) domain proteins act as readers of N6-methyladenosine (m6A) in mRNA. Members of the YTHDF clade determine properties of m6A-containing mRNAs in the cytoplasm. Vertebrates encode three YTHDF...
7.
Lopez-Marquez D, Del-Espino A, Ruiz-Albert J, R Bejarano E, Brodersen P, Beuzon C
J Exp Bot . 2023 Jul; 74(19):6052-6068. PMID: 37449766
Plants use different receptors to detect potential pathogens: membrane-anchored pattern recognition receptors (PRRs) activated upon perception of pathogen-associated molecular patterns (PAMPs) that elicit pattern-triggered immunity (PTI); and intracellular nucleotide-binding leucine-rich...
8.
Martinez-Perez M, Aparicio F, Arribas-Hernandez L, Tankmar M, Rennie S, von Bulow S, et al.
EMBO J . 2023 Jul; 42(18):e113378. PMID: 37431920
In virus-host interactions, nucleic acid-directed first lines of defense that allow viral clearance without compromising growth are of paramount importance. Plants use the RNA interference pathway as a basal antiviral...
9.
Bressendorff S, Kausika S, Sjogaard I, Oksbjerg E, Michels A, Poulsen C, et al.
Biochem J . 2023 Jun; 480(13):957-974. PMID: 37278687
The effector complex of RNA interference (RNAi) contains at its core an ARGONAUTE (AGO) protein bound to a small guide RNA. AGO proteins adopt a two-lobed structure in which the...
10.
Thieffry A, Lopez-Marquez D, Bornholdt J, Malekroudi M, Bressendorff S, Barghetti A, et al.
Plant Cell . 2022 Apr; 34(7):2615-2637. PMID: 35404429
Immune responses triggered by pathogen-associated molecular patterns (PAMPs) are key to pathogen defense, but drivers and stabilizers of the growth-to-defense genetic reprogramming remain incompletely understood in plants. Here, we report...