Peter Blomgren
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Explore the profile of Peter Blomgren including associated specialties, affiliations and a list of published articles.
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17
Citations
187
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Recent Articles
1.
Blomgren P, Chandrasekhar J, Di Paolo J, Fung W, Geng G, Ip C, et al.
ACS Med Chem Lett
. 2020 Apr;
11(4):506-513.
PMID: 32292557
Spleen tyrosine kinase (SYK) is a critical regulator of signaling in a variety of immune cell types such as B-cells, monocytes, and macrophages. Accordingly, there have been numerous efforts to...
2.
Discovery of Potent and Selective MTH1 Inhibitors for Oncology: Enabling Rapid Target (In)Validation
Farand J, Kropf J, Blomgren P, Xu J, Schmitt A, Newby Z, et al.
ACS Med Chem Lett
. 2020 Mar;
11(3):358-364.
PMID: 32184970
We describe the discovery of three structurally differentiated potent and selective MTH1 inhibitors and their subsequent use to investigate MTH1 as an oncology target, culminating in target (in)validation. Tetrahydronaphthyridine was...
3.
Wang X, Barbosa J, Blomgren P, Bremer M, Chen J, Crawford J, et al.
ACS Med Chem Lett
. 2017 Jun;
8(6):608-613.
PMID: 28626519
In our continued effort to discover and develop best-in-class Bruton's tyrosine kinase (Btk) inhibitors for the treatment of B-cell lymphomas, rheumatoid arthritis, and systemic lupus erythematosus, we devised a series...
4.
Katewa A, Wang Y, Hackney J, Huang T, Suto E, Ramamoorthi N, et al.
JCI Insight
. 2017 Apr;
2(7):e90111.
PMID: 28405610
Systemic lupus erythematosus (SLE) is often associated with exaggerated B cell activation promoting plasma cell generation, immune-complex deposition in the kidney, renal infiltration of myeloid cells, and glomerular nephritis. Type-I...
5.
Young W, Barbosa J, Blomgren P, Bremer M, Crawford J, Dambach D, et al.
Bioorg Med Chem Lett
. 2015 Dec;
26(2):575-579.
PMID: 26675441
BTK inhibitor GDC-0834 (1) was found to be rapidly metabolized in human studies, resulting in a suspension of clinical trials. The primary route of metabolism was through cleavage of the...
6.
Young W, Barbosa J, Blomgren P, Bremer M, Crawford J, Dambach D, et al.
Bioorg Med Chem Lett
. 2015 Feb;
25(6):1333-7.
PMID: 25701252
SAR studies focused on improving the pharmacokinetic (PK) properties of the previously reported potent and selective Btk inhibitor CGI-1746 (1) resulted in the clinical candidate GDC-0834 (2), which retained the...
7.
Currie K, Kropf J, Lee T, Blomgren P, Xu J, Zhao Z, et al.
J Med Chem
. 2014 May;
57(9):3856-73.
PMID: 24779514
Spleen tyrosine kinase (Syk) is an attractive drug target in autoimmune, inflammatory, and oncology disease indications. The most advanced Syk inhibitor, R406, 1 (or its prodrug form fostamatinib, 2), has...
8.
Bazan C, Hawkins T, Torres-Barba D, Blomgren P, Paolini P
BMC Biophys
. 2011 Aug;
4:17.
PMID: 21854653
Background: We are exploring the viability of a novel approach to cardiocyte contractility assessment based on biomechanical properties of the cardiac cells, energy conservation principles, and information content measures. We...
9.
Bazan C, Barba D, Blomgren P, Paolini P
Int J Biomed Imaging
. 2011 Aug;
2011:729732.
PMID: 21826135
We describe a computational framework for the quantitative assessment of contractile responses of isolated neonatal cardiac myocytes. To the best of our knowledge, this is the first report on a...
10.
Bazan C, Barba D, Blomgren P, Paolini P
Int J Biomed Imaging
. 2010 Mar;
2009:352954.
PMID: 20224633
We describe a computational framework for the comprehensive assessment of contractile responses of enzymatically dissociated adult cardiac myocytes. The proposed methodology comprises the following stages: digital video recording of the...