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Pei-Qiang Huang

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Articles 108
Citations 764
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Recent Articles
1.
Lu G, Ruan Z, Wang Y, Lu J, Ye J, Huang P
Angew Chem Int Ed Engl . 2024 Dec; :e202422742. PMID: 39655429
Reported herein is a convenient and efficient method for one-pot, catalytic reductive amination, as well as the first multi-component tandem reductive amination-functionalization of bench-stable and readily available common carboxylic esters....
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Xu F, Chen J, Shao D, Huang P
Nat Commun . 2023 Oct; 14(1):6251. PMID: 37803030
The primary objective in synthetic organic chemistry is to develop highly efficient, selective, and versatile synthetic methodologies, which are essential for discovering new drug candidates and agrochemicals. In this study,...
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Ji K, He S, Xu D, He W, Zheng J, Huang P
Angew Chem Int Ed Engl . 2023 Apr; 62(25):e202302832. PMID: 37025034
A concise asymmetric total synthesis of (-)-quinocarcin has been accomplished with high step economy from commercially available starting materials. A catalytic enantioselective reductive 1,3-dipolar cycloaddition reaction of N-heteroaryl secondary amides...
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Chen H, Wu Z, Shao D, Huang P
Sci Adv . 2022 Nov; 8(47):eade3431. PMID: 36417504
The catalytic asymmetric geminal bis-nucleophilic addition to nonreactive functional groups is a type of highly desirable yet challenging transformation in organic chemistry. Here, we report the first catalytic asymmetric reductive/deoxygenative...
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Wu D, Ou W, Huang P
Org Lett . 2022 Jul; 24(29):5366-5371. PMID: 35849542
The catalytic reductive condensation reactions of tertiary amides with active methylene compounds leading to multifunctionalized non--containing products is described. The reactions proceed through sequential iridium-catalyzed hydrosilylation of the amides followed...
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Hong Y, Ye J, Huang P
J Org Chem . 2022 Jun; 87(14):9044-9055. PMID: 35748643
A versatile synthesis of α-amino bisphosphonates has been achieved through one-pot interrupted Ritter-type reaction under mild conditions. The reactive Ritter intermediate nitrilium is generated by treatment of nitrile with readily...
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Yu S, Ye J, Hong Y, Huang P
J Org Chem . 2021 Nov; 86(23):16926-16939. PMID: 34752091
In this paper, we document the construction of functionalized and fused eight-membered carbocycles by the triflic anhydride-mediated cyclization of 7-enamides. Taking advantage of the high electrophilicity of the nitrilium ion...
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Li Z, Zhao F, Ou W, Huang P, Wang X
Angew Chem Int Ed Engl . 2021 Oct; 60(51):26604-26609. PMID: 34596947
A variety of inert tertiary amides have been successfully transformed into synthetically important chiral propargylamines in high yields with good to excellent enantioselectivities via a relayed sequence of Ir catalyzed...
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He Q, Ye J, Xu F, Geng H, Chen T, Chen H, et al.
J Org Chem . 2021 Sep; 86(23):16300-16314. PMID: 34499513
Ten types of TfO/TTBP-mediated amide transformation reactions were investigated. The results showed that compared with pyridine derivatives 2,6-di--butyl-4-methylpyridine (DTBMP) and 2-fluoropyridine (2-F-Pyr.), TTBP can serve as an alternative amide activation...