Pedro Zuazua-Villar
Overview
Explore the profile of Pedro Zuazua-Villar including associated specialties, affiliations and a list of published articles.
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10
Citations
202
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Recent Articles
1.
Pantelejevs T, Zuazua-Villar P, Koczy O, Counsell A, Walsh S, Robertson N, et al.
Chem Sci
. 2023 Dec;
14(47):13915-13923.
PMID: 38075664
Stapling is a macrocyclisation method that connects amino acid side chains of a peptide to improve its pharmacological properties. We describe an approach for stapled peptide preparation and biochemical evaluation...
2.
Schiavoni F, Zuazua-Villar P, Roumeliotis T, Benstead-Hume G, Pardo M, Pearl F, et al.
Nat Commun
. 2022 Apr;
13(1):1731.
PMID: 35365638
Aneuploidy results in decreased cellular fitness in many species and model systems. However, aneuploidy is commonly found in cancer cells and often correlates with aggressive growth, suggesting that the impact...
3.
Lindenburg L, Pantelejevs T, Gielen F, Zuazua-Villar P, Butz M, Rees E, et al.
Proc Natl Acad Sci U S A
. 2021 Nov;
118(46).
PMID: 34772801
Exchanges of protein sequence modules support leaps in function unavailable through point mutations during evolution. Here we study the role of the two RAD51-interacting modules within the eight binding BRC...
4.
Zuazua-Villar P, Ganesh A, Phear G, Gagou M, Meuth M
Nucleic Acids Res
. 2015 Aug;
43(20):9776-87.
PMID: 26271993
The replication protein A (RPA)-ssDNA complex formed at arrested replication forks recruits key proteins to activate the ATR-CHK1 signalling cascade. When CHK1 is inhibited during DNA replication stress, RPA2 is...
5.
Gagou M, Zuazua-Villar P, Meuth M
Mol Biol Cell
. 2010 Jan;
21(5):739-52.
PMID: 20053681
H2AX phosphorylation at serine 139 (gammaH2AX) is a sensitive indicator of both DNA damage and DNA replication stress. Here we show that gammaH2AX formation is greatly enhanced in response to...
6.
Myers K, Gagou M, Zuazua-Villar P, Rodriguez R, Meuth M
PLoS Genet
. 2009 Jan;
5(1):e1000324.
PMID: 19119425
The related PIK-like kinases Ataxia-Telangiectasia Mutated (ATM) and ATM- and Rad3-related (ATR) play major roles in the regulation of cellular responses to DNA damage or replication stress. The pro-apoptotic role...
7.
Casado P, Prado M, Zuazua-Villar P, Del Valle E, Artime N, Cabal-Hierro L, et al.
J Proteomics
. 2008 Oct;
71(6):592-600.
PMID: 18832053
Microtubule interfering agents (MIAs) are anti-tumor drugs that inhibit microtubule dynamics, while kinesin spindle protein (KSP) inhibitors are substances that block the formation of the bipolar spindle during mitosis. All...
8.
Prado M, Casado P, Zuazua-Villar P, Del Valle E, Artime N, Cabal-Hierro L, et al.
Proteomics
. 2007 Aug;
7(18):3299-304.
PMID: 17708594
Paclitaxel (Ptx) is an antitumoural drug that inhibits microtubule dynamics, causes G2/M arrest and induces cell death. 2-D PAGE and MALDI-TOF-MS analysis of HeLa cells extracts revealed that Ptx up-regulates...
9.
Casado P, Zuazua-Villar P, Prado M, Del Valle E, Iglesias J, Martinez-Campa C, et al.
Arch Biochem Biophys
. 2007 Mar;
461(1):123-9.
PMID: 17367746
Vincristine and paclitaxel are widely used antitumoral drugs that interfere with microtubule dynamics. We have previously demonstrated that vincristine induces phosphorylation of HSP27 at serine 82 in MCF-7 cells. In...
10.
Casado P, Zuazua-Villar P, Del Valle E, Martinez-Campa C, Lazo P, Ramos S
Cancer Lett
. 2006 Jul;
247(2):273-82.
PMID: 16843591
Vincristine is an antitumor drug that inhibits microtubule polymerization, causes G2/M arrest and induces apoptosis. 2D-PAGE and MALDI-TOF-MS analysis of vincristine effects on MCF7 cells, revealed a vincristine upregulated form...