Pawel Mikulski
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Explore the profile of Pawel Mikulski including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
177
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Recent Articles
1.
Tehrani S, Kogan A, Mikulski P, Jansen L
Cell Death Differ
. 2023 Aug;
32(1):16-26.
PMID: 37563261
Transcriptional memory is characterized by a primed cellular state, induced by an external stimulus that results in an altered expression of primed genes upon re-exposure to the inducing signal. Intriguingly,...
2.
Mikulski P, Santos-Aberturas J
Plant Environ Interact
. 2023 Jun;
3(1):10-15.
PMID: 37283691
Stress memory is a phenomenon whereby exposure to initial stress event influences a response to subsequent stress exposures. Studying stress memory is important to understand the cellular behavior in dynamic...
3.
Tehrani S, Mikulski P, Abdul-Zani I, Mata J, Siwek W, Jansen L
EMBO J
. 2023 Jun;
42(14):e112259.
PMID: 37272165
Exposure of human cells to interferon-γ (IFNγ) results in a mitotically heritable yet reversible state called long-term transcriptional memory. We previously identified the clustered GBP genes as strongly primed by...
4.
Mikulski P, Wolff P, Lu T, Nielsen M, Echevarria E, Zhu D, et al.
Nat Commun
. 2022 Sep;
13(1):5542.
PMID: 36130923
Polycomb (PcG) silencing is crucial for development, but how targets are specified remains incompletely understood. The cold-induced Polycomb Repressive Complex 2 (PRC2) silencing of Arabidopsis thaliana FLOWERING LOCUS C (FLC)...
5.
Yang M, Zhu P, Cheema J, Bloomer R, Mikulski P, Liu Q, et al.
Nature
. 2022 Aug;
609(7926):394-399.
PMID: 35978193
Cellular RNAs are heterogeneous with respect to their alternative processing and secondary structures, but the functional importance of this complexity is still poorly understood. A set of alternatively processed antisense...
6.
Lovkvist C, Mikulski P, Reeck S, Hartley M, Dean C, Howard M
Elife
. 2021 Sep;
10.
PMID: 34473050
The histone modification H3K27me3 plays a central role in Polycomb-mediated epigenetic silencing. H3K27me3 recruits and allosterically activates Polycomb Repressive Complex 2 (PRC2), which adds this modification to nearby histones, providing...
7.
Kalyanikrishna , Mikulski P, Schubert D
Methods Mol Biol
. 2020 Feb;
2093:107-113.
PMID: 32088892
Gene expression is tightly linked to the position of genes in the nucleus. Genomic regions associated with the nuclear envelope are usually repressed, including the heterochromatin carrying chromocenters. The shape...
8.
Mikulski P, Hohenstatt M, Farrona S, Smaczniak C, Stahl Y, Kalyanikrishna , et al.
Plant Cell
. 2019 Mar;
31(5):1141-1154.
PMID: 30914470
Spatial organization of chromatin contributes to gene regulation of many cellular processes and includes a connection of chromatin with the nuclear lamina (NL). The NL is a protein mesh that...
9.
Hohenstatt M, Mikulski P, Komarynets O, Klose C, Kycia I, Jeltsch A, et al.
Plant Cell
. 2018 Jan;
30(1):117-133.
PMID: 29330200
Polycomb-group (PcG) proteins mediate epigenetic gene regulation by setting H3K27me3 via Polycomb Repressive Complex 2 (PRC2). In plants, it is largely unclear how PcG proteins are recruited to their target...
10.
Mikulski P, Komarynets O, Fachinelli F, Weber A, Schubert D
Front Plant Sci
. 2017 May;
8:607.
PMID: 28491069
Polycomb Group (PcG) proteins mediate chromatin repression in plants and animals by catalyzing H3K27 methylation and H2AK118/119 mono-ubiquitination through the activity of the Polycomb repressive complex 2 (PRC2) and PRC1,...