Pavlina Baevova
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Explore the profile of Pavlina Baevova including associated specialties, affiliations and a list of published articles.
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12
Citations
229
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Recent Articles
1.
Leiby K, Yuan Y, Ng R, Raredon M, Adams T, Baevova P, et al.
NPJ Regen Med
. 2023 Apr;
8(1):22.
PMID: 37117221
Engineered whole lungs may one day expand therapeutic options for patients with end-stage lung disease. However, the feasibility of ex vivo lung regeneration remains limited by the inability to recapitulate...
2.
Raredon M, Fisher C, Heerdt P, Schonberger R, Nargi A, Nivison S, et al.
Anesth Analg
. 2021 Dec;
134(5):1094-1105.
PMID: 34928890
The coronavirus disease 2019 (COVID-19) pandemic has revealed that even the best-resourced hospitals may lack sufficient ventilators to support patients under surge conditions. During a pandemic or mass trauma, an...
3.
Yuan Y, Leiby K, Greaney A, Raredon M, Qian H, Schupp J, et al.
Front Bioeng Biotechnol
. 2021 Dec;
9:760309.
PMID: 34869270
The development of an system for the study of lung vascular disease is critical to understanding human pathologies. Conventional culture systems fail to fully recapitulate native microenvironmental conditions and are...
4.
Le A, Hatachi G, Beloiartsev A, Ghaedi M, Engler A, Baevova P, et al.
ACS Biomater Sci Eng
. 2021 Jan;
3(9):2000-2010.
PMID: 33440555
To date, efforts to generate engineered lung tissue capable of long-term function have been limited by incomplete barrier formation between air and blood and by thrombosis of the microvasculature upon...
5.
Engler A, Raredon M, Le A, Yuan Y, Oczkowicz Y, Kan E, et al.
Biomaterials
. 2019 Jul;
217:119313.
PMID: 31280072
Microvascular leak is a phenomenon witnessed in multiple disease states. In organ engineering, regaining a functional barrier is the most crucial step towards creating an implantable organ. All previous methods...
6.
Yuan Y, Engler A, Raredon M, Le A, Baevova P, Yoder M, et al.
Biomaterials
. 2019 Feb;
200:25-34.
PMID: 30754017
Whole organ engineering paradigms typically involve repopulating acellular organ scaffolds with recipient-compatible cells, to generate a neo-organ that may provide key physiological functions. In the case of whole lung engineering,...
7.
Ghaedi M, Le A, Hatachi G, Beloiartsev A, Rocco K, Sivarapatna A, et al.
J Tissue Eng Regen Med
. 2017 Oct;
12(3):e1623-e1635.
PMID: 29024475
The development of an alternative source for donor lungs would change the paradigm of lung transplantation. Recent studies have demonstrated the potential feasibility of using decellularized lungs as scaffolds for...
8.
Engler A, Le A, Baevova P, Niklason L
J Tissue Eng Regen Med
. 2017 Jan;
12(1):e119-e129.
PMID: 28083925
In cellular, tissue-level or whole organ bioreactors, the level of dissolved oxygen is one of the most important factors requiring control. Hypoxic environments may lead to cellular apoptosis, while hyperoxic...
9.
Balestrini J, Gard A, Gerhold K, Wilcox E, Liu A, Schwan J, et al.
Biomaterials
. 2016 Jun;
102:220-30.
PMID: 27344365
Lung engineering is a promising technology, relying on re-seeding of either human or xenographic decellularized matrices with patient-derived pulmonary cells. Little is known about the species-specificity of decellularization in various...
10.
Elliott D, McIntosh M, Hosgood 3rd H, Chen S, Zhang G, Baevova P, et al.
Proc Natl Acad Sci U S A
. 2008 Feb;
105(7):2463-8.
PMID: 18263733
During the bloodstage of malaria infection, the parasite internalizes and degrades massive amounts of hemoglobin from the host red blood cell. Using serial thin-section electron microscopy and three-dimensional reconstruction, we...