Pavel Tsaytler
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Explore the profile of Pavel Tsaytler including associated specialties, affiliations and a list of published articles.
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7
Citations
696
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Recent Articles
1.
Swanepoel C, Wang G, Zhang L, Brandl B, Bauer H, Tsaytler P, et al.
bioRxiv
. 2025 Feb;
PMID: 39975218
Mendelian genetics posits equal transmission of alleles, but selfish alleles can bias the transmission of large genomic regions or entire chromosomes. One long-standing question is how transmission bias evolves to...
2.
Tsaytler P, Blaess G, Scholze-Wittler M, Meierhofer D, Wittler L, Koch F, et al.
Cell Rep
. 2024 Oct;
43(10):114846.
PMID: 39392751
Serum response factor (SRF) is a transcription factor essential for cell proliferation, differentiation, and migration and is required for primitive streak and mesoderm formation in the embryo. The canonical roles...
3.
Tsaytler P, Blaess G, Scholze-Wittler M, Koch F, Herrmann B
Stem Cell Reports
. 2024 Apr;
19(5):618-628.
PMID: 38579708
SOX2 is a transcription factor involved in the regulatory network maintaining the pluripotency of embryonic stem cells in culture as well as in early embryos. In addition, SOX2 plays a...
4.
Tsaytler P, Liu J, Blaess G, Schifferl D, Veenvliet J, Wittler L, et al.
Development
. 2023 Apr;
150(10).
PMID: 37082965
Cardiac lineage specification in the mouse is controlled by TGFβ and WNT signaling. From fly to fish, BMP has been identified as an indispensable heart inducer. A detailed analysis of...
5.
Beisaw A, Tsaytler P, Koch F, Schmitz S, Melissari M, Senft A, et al.
EMBO Rep
. 2017 Nov;
19(1):118-134.
PMID: 29141987
T-box transcription factors play essential roles in multiple aspects of vertebrate development. Here, we show that cooperative function of BRACHYURY (T) with histone-modifying enzymes is essential for mouse embryogenesis. A...
6.
Moreno J, Radford H, Peretti D, Steinert J, Verity N, Martin M, et al.
Nature
. 2012 May;
485(7399):507-11.
PMID: 22622579
The mechanisms leading to neuronal death in neurodegenerative disease are poorly understood. Many of these disorders, including Alzheimer's, Parkinson's and prion diseases, are associated with the accumulation of misfolded disease-specific...
7.
Tsaytler P, Bertolotti A
FEBS J
. 2012 Feb;
280(2):766-70.
PMID: 22340633
Selective and reversible phosphorylation is one of the most common post-translational modifications of proteins. Although kinase inhibitors are popular in drug development programmes, selective pharmacological manipulation of phosphatase activity has...
8.
Tsaytler P, Harding H, Ron D, Bertolotti A
Science
. 2011 Mar;
332(6025):91-4.
PMID: 21385720
Many biological processes are regulated through the selective dephosphorylation of proteins. Protein serine-threonine phosphatases are assembled from catalytic subunits bound to diverse regulatory subunits that provide substrate specificity and subcellular...