Pavel Pichurin
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Explore the profile of Pavel Pichurin including associated specialties, affiliations and a list of published articles.
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Citations
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Recent Articles
11.
Wain K, Ellingson M, McDonald J, Gammon A, Roberts M, Pichurin P, et al.
Genet Med
. 2014 Feb;
16(8):588-93.
PMID: 24525918
Heterozygous loss-of-function SMAD4 mutations are associated with juvenile polyposis syndrome and hereditary hemorrhagic telangiectasia. Some carriers exhibit symptoms of both conditions, leading to juvenile polyposis-hereditary hemorrhagic telangiectasia syndrome. Three families...
12.
Pichurin P, Pham N, David C, Rapoport B, McLachlan S
Thyroid
. 2007 Jan;
16(12):1221-7.
PMID: 17199432
The major histocompatibility (MHC) molecule HLA-DR3 is a susceptibility gene for Graves' disease (GD) in Caucasians. Mice lacking murine MHC and expressing human HLA-DR3 develop thyrotropin receptor (TSHR) antibodies and...
13.
Latrofa F, Chazenbalk G, Pichurin P, Chen C, McLachlan S, Rapoport B
J Clin Endocrinol Metab
. 2004 Sep;
89(9):4734-45.
PMID: 15356088
We used purified recombinant TSH receptor (TSHR) antigen prepared in mammalian cells to affinity-enrich TSHR autoantibodies from Graves' patients' IgG. Autoantibody enrichment, assayed by TSH binding inhibitory activity, was 20-...
14.
Pichurin P, Chen C, Pichurina O, David C, Rapoport B, McLachlan S
Thyroid
. 2003 Nov;
13(10):911-7.
PMID: 14611699
Graves' disease in Caucasians is associated with the major histocompatibility (MHC) antigen HLA-DR3. One approach to studying the role of susceptibility genes involves the use of mice that lack murine...
15.
Chen C, Pichurin P, Chazenbalk G, Aliesky H, Nagayama Y, McLachlan S, et al.
Endocrinology
. 2003 Oct;
145(1):228-33.
PMID: 14576177
Immunization with adenovirus expressing the TSH receptor (TSHR) induces hyperthyroidism in 25-50% of mice. Even more effective is immunization with a TSHR A-subunit adenovirus (65-84% hyperthyroidism). Nevertheless, TSHR antibody characteristics...
16.
Chen C, Pichurin P, Nagayama Y, Latrofa F, Rapoport B, McLachlan S
J Clin Invest
. 2003 Jun;
111(12):1897-904.
PMID: 12813025
Graves disease, a common organ-specific autoimmune disease affecting humans, differs from all other autoimmune diseases in being associated with target organ hyperfunction rather than organ damage. Clinical thyrotoxicosis is directly...
17.
Latrofa F, Pichurin P, Guo J, Rapoport B, McLachlan S
J Clin Endocrinol Metab
. 2003 Jan;
88(1):371-8.
PMID: 12519879
Autoantibodies (Ab) to thyroglobulin (Tg) and to thyroid peroxidase (TPO) are reported to share common epitopes, and an assay for bispecific TgPOAb has been developed that may distinguish between different...
18.
Pichurin P, Schwarz-Lauer L, Braley-Mullen H, Paras C, Pichurina O, Morris J, et al.
Thyroid
. 2002 Dec;
12(9):755-64.
PMID: 12481940
Vaccinating mice with DNA encoding the thyrotropin receptor (TSHR), the major autoantigen in Graves' disease, induces memory T cells that secrete interferon-gamma (IFN-gamma) in response to TSHR antigen. We used...
19.
Chazenbalk G, Pichurin P, Chen C, Latrofa F, Johnstone A, McLachlan S, et al.
J Clin Invest
. 2002 Jul;
110(2):209-17.
PMID: 12122113
Graves disease is directly caused by thyroid-stimulating autoantibodies (TSAb's) that activate the thyrotropin receptor (TSHR). We observed upon flow cytometry using intact cells that a mouse mAb (3BD10) recognized the...
20.
Pichurin P, Pichurina O, Chazenbalk G, Paras C, Chen C, Rapoport B, et al.
Endocrinology
. 2002 Mar;
143(4):1182-9.
PMID: 11897670
TSH receptor (TSHR) DNA vaccination induces high TSHR antibody levels in BALB/c mice housed in a conventional facility. However, under pathogen-free conditions, we observed a Th1 cellular response to TSHR...