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Pauline Sararols

Explore the profile of Pauline Sararols including associated specialties, affiliations and a list of published articles. Areas
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Articles 7
Citations 119
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Recent Articles
1.
Neirijnck Y, Sararols P, Kuhne F, Mayere C, Weerasinghe Arachchige L, Regard V, et al.
Cell Rep . 2023 Mar; 42(3):112191. PMID: 36862551
Adrenal cortex and gonads represent the two major steroidogenic organs in mammals. Both tissues are considered to share a common developmental origin characterized by the expression of Nr5a1/Sf1. The precise...
2.
Ademi H, Djari C, Mayere C, Neirijnck Y, Sararols P, Rands C, et al.
Cell Rep . 2022 Jun; 39(11):110935. PMID: 35705036
Leydig cells (LCs) are the major androgen-producing cells in the testis. They arise from steroidogenic progenitors (SPs), whose origins, maintenance, and differentiation dynamics remain largely unknown. Single-cell transcriptomics reveal that...
3.
Mayere C, Regard V, Perea-Gomez A, Bunce C, Neirijnck Y, Djari C, et al.
Sci Adv . 2022 May; 8(21):eabm0972. PMID: 35613264
Gonadal sex determination represents a unique model for studying cell fate decisions. However, a complete understanding of the different cell lineages forming the developing testis and ovary remains elusive. Here,...
4.
Sararols P, Stevant I, Neirijnck Y, Rebourcet D, Darbey A, Curley M, et al.
Front Cell Dev Biol . 2021 Jul; 9:695546. PMID: 34262907
Leydig cells (LC) are the main testicular androgen-producing cells. In eutherian mammals, two types of LCs emerge successively during testicular development, fetal Leydig cells (FLCs) and adult Leydig cells (ALCs)....
5.
Mayere C, Neirijnck Y, Sararols P, Rands C, Stevant I, Kuhne F, et al.
FASEB J . 2021 Mar; 35(4):e21452. PMID: 33749946
Despite the importance of germ cell (GC) differentiation for sexual reproduction, the gene networks underlying their fate remain unclear. Here, we comprehensively characterize the gene expression dynamics during sex determination...
6.
Neirijnck Y, Kuhne F, Mayere C, Pavlova E, Sararols P, Foti M, et al.
Endocrinology . 2018 Dec; 160(2):387-398. PMID: 30576429
The IGFs are the major intratesticular factors regulating immature Sertoli cell proliferation and are, therefore, critical to establish the magnitude of sperm production. However, the intratesticular source of IGF production...
7.
Ilaslan E, Calvel P, Nowak D, Szarras-Czapnik M, Slowikowska-Hilczer J, Spik A, et al.
Sex Dev . 2018 Jun; 12(4):191-195. PMID: 29886504
Identification of novel genes involved in sexual development is crucial for understanding disorders of sex development (DSD). Here, we propose a member of the START domain family, the X chromosome...