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» Authors » Pauline M W van Kempen

Pauline M W van Kempen

Explore the profile of Pauline M W van Kempen including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 17
Citations 303
Followers 0
Related Specialties
Oncology
Pathology
Cell Biology
Top 10 Co-Authors
Stefan M Willems
Robert J J van Es
Wilko Grolman
Rob Noorlag
Weibel W Braunius
Koos Koole
Paul J van Diest
Ron Koole
Justin E Swartz
Inge Stegeman
Published In
Cancer Med
Epigenetics
Pathobiology
Head Neck
Ned Tijdschr Geneeskd
Affiliations
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Recent Articles
11.
Fibroblast Growth Factor Receptor Family Members as Prognostic Biomarkers in Head and Neck Squamous Cell Carcinoma: A Systematic Review
Ipenburg N, Koole K, Liem K, van Kempen P, Koole R, van Diest P, et al.
Target Oncol . 2015 Jun; 11(1):17-27. PMID: 26115874
Background: Since head and neck cancer is characterized by poor survival rates, there is a demand for novel therapeutic targets and prognostic biomarkers. An upcoming therapeutic target is the fibroblast...
12.
Correlation of human papillomavirus status with apparent diffusion coefficient of diffusion-weighted MRI in head and neck squamous cell carcinomas
Driessen J, van Bemmel A, van Kempen P, Janssen L, Terhaard C, Pameijer F, et al.
Head Neck . 2015 Mar; 38 Suppl 1:E613-8. PMID: 25783872
Background: Identification of prognostic patient characteristics in head and neck squamous cell carcinoma (HNSCC) is of great importance. Human papillomavirus (HPV)-positive HNSCCs have favorable response to (chemo)radiotherapy. Apparent diffusion coefficient,...
13.
TP53 Y220C Is a Hotspot Mutation in Oropharyngeal Squamous Cell Carcinoma
van Kempen P, Verdam F, de Poel E, Braunius W, de Weger R, van Es R, et al.
Pathobiology . 2015 Mar; 82(1):21-27. PMID: 25765855
Objectives: Although TP53 mutations in head and neck squamous cell carcinoma (HNSCC) have been extensively studied, their association with the different subsites in the head and neck region has never...
14.
The diagnostic value of 11q13 amplification and protein expression in the detection of nodal metastasis from oral squamous cell carcinoma: a systematic review and meta-analysis
Noorlag R, van Kempen P, Stegeman I, Koole R, van Es R, Willems S
Virchows Arch . 2015 Feb; 466(4):363-73. PMID: 25663615
Despite improvements in both diagnostic and therapeutic strategies, the prognosis of oral squamous cell carcinoma (OSCC) has not changed significantly over the last decades. Prognosis of OSCC particularly depends on...
15.
Promoter hypermethylation using 24-gene array in early head and neck cancer: better outcome in oral than in oropharyngeal cancer
Noorlag R, van Kempen P, Moelans C, De Jong R, Blok L, Koole R, et al.
Epigenetics . 2014 Aug; 9(9):1220-7. PMID: 25147921
Silencing of tumor suppressor genes (TSGs) by DNA promoter hypermethylation is an early event in carcinogenesis and a potential target for personalized cancer treatment. In head and neck cancer, little...
16.
HPV-positive oropharyngeal squamous cell carcinoma is associated with TIMP3 and CADM1 promoter hypermethylation
van Kempen P, van Bockel L, Braunius W, Moelans C, van Olst M, De Jong R, et al.
Cancer Med . 2014 Jul; 3(5):1185-96. PMID: 25065733
Oropharyngeal squamous cell carcinoma (OPSCC) is associated with human papillomavirus (HPV) in a proportion of tumors. HPV-positive OPSCC is considered a distinct molecular entity with a prognostic advantage compared to...
17.
Differences in methylation profiles between HPV-positive and HPV-negative oropharynx squamous cell carcinoma: a systematic review
van Kempen P, Noorlag R, Braunius W, Stegeman I, Willems S, Grolman W
Epigenetics . 2013 Oct; 9(2):194-203. PMID: 24169583
Oropharyngeal squamous cell carcinoma (OPSCC) is associated with human papillomavirus (HPV). HPV-positive OPSCC is considered a distinct molecular entity with a better prognosis than HPV-negative cases of OPSCC. However, the...