Paula Pifarre
Overview
Explore the profile of Paula Pifarre including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
160
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0
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Recent Articles
1.
Ghose R, Aranguren-Ibanez A, Arecco N, Balboa D, Bataller M, Beltran S, et al.
F1000Res
. 2021 Nov;
9:1336.
PMID: 34745570
The COVID-19 pandemic has posed and is continuously posing enormous societal and health challenges worldwide. The research community has mobilized to develop novel projects to find a cure or a...
2.
Diaz-Lucena D, Gutierrez-Mecinas M, Moreno B, Martinez-Sanchez J, Pifarre P, Garcia A
J Neuroimmune Pharmacol
. 2017 Aug;
13(1):6-23.
PMID: 28776122
Remyelination occurs in demyelinated lesions in multiple sclerosis (MS) and pharmacological treatments that enhance this process will critically impact the long term functional outcome in the disease. Sildenafil, a cyclic...
3.
Pifarre P, Gutierrez-Mecinas M, Prado J, Usero L, Roura-Mir C, Giralt M, et al.
Exp Neurol
. 2013 Nov;
251:58-71.
PMID: 24211383
In addition to detrimental inflammation, widespread axon degeneration is an important feature of multiple sclerosis (MS) pathology and a major correlate for permanent clinical deficits. Thus, treatments that combine immunomodulatory...
4.
Giralt M, Ramos R, Quintana A, Ferrer B, Erta M, Castro-Freire M, et al.
Glia
. 2013 Jan;
61(4):587-600.
PMID: 23322593
Interleukin (IL)-6 is crucial for the induction of many murine models of autoimmunity including experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. While IL-6-deficient mice (IL-6 KO) are...
5.
Metallothioneins I/II are involved in the neuroprotective effect of sildenafil in focal brain injury
Prado J, Pifarre P, Giralt M, Hidalgo J, Garcia A
Neurochem Int
. 2012 Nov;
62(1):70-8.
PMID: 23178801
We recently reported that administration of the non-selective cyclic GMP-phosphodiesterase (cGMP-PDE) inhibitor zaprinast to cortically cryoinjured rats results three days post-lesion in reduced neuronal cell death that was associated to...
6.
Pifarre P, Prado J, Baltrons M, Giralt M, Gabarro P, Feinstein D, et al.
Acta Neuropathol
. 2011 Jan;
121(4):499-508.
PMID: 21234581
Cyclic GMP (cGMP)-mediated pathways regulate inflammatory responses in immune and CNS cells. Recently, cGMP phosphodiesterase inhibitors such as sildenafil, commonly used to treat sexual dysfunction in humans including multiple sclerosis...
7.
Prado J, Baltrons M, Pifarre P, Garcia A
Neurochem Int
. 2010 Mar;
57(4):367-74.
PMID: 20302900
Natriuretic peptides and their receptors are widely expressed in mammalian CNS and increasing evidence implicates them in the regulation of neural development, synaptic transmission and processing of information, and neuroprotection....
8.
Pifarre P, Prado J, Giralt M, Molinero A, Hidalgo J, Garcia A
J Neurochem
. 2009 Dec;
112(3):807-17.
PMID: 20002517
Recent evidence obtained in cultured glial cells indicates that cGMP-mediated pathways regulate cytoskeleton dynamics, glial fibrillary acidic protein expression and motility in astrocytes, as well as inflammatory gene expression in...
9.
Pifarre P, Baltrons M, Foldi I, Garcia A
Int J Biochem Cell Biol
. 2009 May;
41(8-9):1719-30.
PMID: 19433313
NO-sensitive guanylyl cyclase (GC(NO)), the major NO target, is involved in important regulatory functions in the cardiovascular, gastrointestinal and central nervous systems. GC(NO) exists as heterodimers of alpha(1/2) and beta1...
10.
Baltrons M, Boran M, Pifarre P, Garcia A
Neurochem Res
. 2008 Apr;
33(12):2427-35.
PMID: 18379874
A large body of evidence supports a role for the NO-cGMP-protein kinase G pathway in the regulation of synaptic transmission and plasticity, brain development and neuroprotection. Circumstantial evidence implicates natriuretic...