Paula P Coelho
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Explore the profile of Paula P Coelho including associated specialties, affiliations and a list of published articles.
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7
Citations
223
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Recent Articles
1.
Kuzmin E, Baker T, Lesluyes T, Monlong J, Abe K, Coelho P, et al.
Cell Rep
. 2024 Mar;
43(4):113988.
PMID: 38517886
The basal breast cancer subtype is enriched for triple-negative breast cancer (TNBC) and displays consistent large chromosomal deletions. Here, we characterize evolution and maintenance of chromosome 4p (chr4p) loss in...
2.
Coelho P, Park M
Autophagy
. 2022 Aug;
19(4):1354-1356.
PMID: 36026467
Macroautophagy/autophagy acts to promote homeostasis and is increasingly understood to selectively target cargo for degradation. The LC3-family of proteins mediate diverse yet distinct cargo recruitment to phagophores. However, what underlies...
3.
Coelho P, Hesketh G, Pedersen A, Kuzmin E, Fortier A, Bell E, et al.
Nat Commun
. 2022 Jul;
13(1):3812.
PMID: 35780247
Autophagy selectively targets cargo for degradation, yet mechanistic understanding remains incomplete. The ATG8-family plays key roles in autophagic cargo recruitment. Here by mapping the proximal interactome of ATG8-paralogs, LC3B and...
4.
Ratcliffe C, Siddiqui N, Coelho P, Laterreur N, Cookey T, Sonenberg N, et al.
J Cell Biol
. 2018 Nov;
218(1):285-298.
PMID: 30404949
Differential inclusion or skipping of microexons is an increasingly recognized class of alternative splicing events. However, the functional significance of microexons and their contribution to signaling diversity is poorly understood....
5.
Knight J, Sung V, Kuzmin E, Couzens A, de Verteuil D, Ratcliffe C, et al.
Cell Rep
. 2018 Mar;
22(12):3191-3205.
PMID: 29562176
Triple-negative breast cancers (TNBCs) display a complex spectrum of mutations and chromosomal aberrations. Chromosome 5q (5q) loss is detected in up to 70% of TNBCs, but little is known regarding...
6.
Rajadurai C, Havrylov S, Coelho P, Ratcliffe C, Zaoui K, Huang B, et al.
J Cell Biol
. 2016 Sep;
214(6):719-34.
PMID: 27597754
Invadopodia are specialized membrane protrusions that support degradation of extracellular matrix (ECM) by cancer cells, allowing invasion and metastatic spread. Although early stages of invadopodia assembly have been elucidated, little...
7.
Vincent E, Sergushichev A, Griss T, Gingras M, Samborska B, NTimbane T, et al.
Mol Cell
. 2015 Oct;
60(2):195-207.
PMID: 26474064
Cancer cells adapt metabolically to proliferate under nutrient limitation. Here we used combined transcriptional-metabolomic network analysis to identify metabolic pathways that support glucose-independent tumor cell proliferation. We found that glucose...