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Paula K Greer

Explore the profile of Paula K Greer including associated specialties, affiliations and a list of published articles. Areas
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Articles 26
Citations 707
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Recent Articles
1.
Sun M, Yang R, Liu H, Wang W, Song X, Hu B, et al.
Cancers (Basel) . 2023 Sep; 15(18). PMID: 37760589
Brain tumor-initiating cells (BTICs) and tumor cell plasticity promote glioblastoma (GBM) progression. Here, we demonstrate that clemastine, an over-the-counter drug for treating hay fever and allergy symptoms, effectively attenuated the...
2.
Singh S, Yang R, Roso K, Hansen L, Du C, Chen L, et al.
Biomedicines . 2022 Apr; 10(4). PMID: 35453502
Glioblastoma (GBM) is a lethal brain cancer exhibiting high levels of drug resistance, a feature partially imparted by tumor cell stemness. Recent work shows that homozygous deletion, a genetic alteration...
3.
Xu C, Liu H, Pirozzi C, Chen L, Greer P, Diplas B, et al.
Acta Neuropathol Commun . 2021 Nov; 9(1):178. PMID: 34732238
Diffuse intrinsic pontine gliomas (DIPGs) are high-grade tumors of the brainstem that often occur in children, with a median overall survival of less than one year. Given the fact that...
4.
Wang Z, Xu C, Diplas B, Moure C, Chen C, Chen L, et al.
Mol Cancer Res . 2020 Apr; 18(7):968-980. PMID: 32229503
Diffuse intrinsic pontine glioma (DIPG) is an invariably fatal brain tumor occurring predominantly in children. Up to 90% of pediatric DIPGs harbor a somatic heterozygous mutation resulting in the replacement...
5.
Du C, Hansen L, Singh S, Wang F, Sun R, Moure C, et al.
Cell Rep . 2019 Sep; 28(12):3199-3211.e5. PMID: 31533041
H2AX safeguards genomic stability in a dose-dependent manner; however, mechanisms governing its proteostasis are poorly understood. Here, we identify a PRMT5-RNF168-SMURF2 cascade that regulates H2AX proteostasis. We show that PRMT5...
6.
Hansen L, Sun R, Yang R, Singh S, Chen L, Pirozzi C, et al.
Cancer Res . 2019 May; 79(13):3383-3394. PMID: 31040154
Homozygous deletion of methylthioadenosine phosphorylase () is one of the most frequent genetic alterations in glioblastoma (GBM), but its pathologic consequences remain unclear. In this study, we report that loss...
7.
Liu Y, Carpenter A, Pirozzi C, Yuan H, Waitkus M, Zhou Z, et al.
Nanotechnology . 2019 Mar; 30(27):275101. PMID: 30856613
Despite decades of efforts, non-invasive sensitive detection of small malignant brain tumors still remains challenging. Here we report a dual-modality I-labeled gold nanostar (I-GNS) probe for sensitive brain tumor imaging...
8.
Lei K, Sun R, Chen L, Diplas B, Moure C, Wang W, et al.
Sci Rep . 2018 Aug; 8(1):12507. PMID: 30131529
The concept that human cancer is in essence a genetic disease driven by gene mutations has been well established, yet its utilization in functional studies of cancer genes has not...
9.
Diplas B, He X, Brosnan-Cashman J, Liu H, Chen L, Wang Z, et al.
Nat Commun . 2018 May; 9(1):2087. PMID: 29802247
The majority of glioblastomas can be classified into molecular subgroups based on mutations in the TERT promoter (TERTp) and isocitrate dehydrogenase 1 or 2 (IDH). These molecular subgroups utilize distinct...
10.
Hale L, Kant E, Greer P, Foster W
PLoS One . 2017 Dec; 9(1). PMID: 29220837
[This corrects the article DOI: 10.1371/journal.pone.0045667.].