Paula J McKeown-Longo
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Explore the profile of Paula J McKeown-Longo including associated specialties, affiliations and a list of published articles.
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35
Citations
654
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Recent Articles
1.
Maddali P, Ambesi A, McKeown-Longo P
PLoS One
. 2023 May;
18(5):e0286390.
PMID: 37228128
Changes in the organization and structure of the fibronectin matrix are believed to contribute to dysregulated wound healing and subsequent tissue inflammation and tissue fibrosis. These changes include an increase...
2.
Ambesi A, Maddali P, McKeown-Longo P
Cells
. 2022 Jul;
11(13).
PMID: 35805158
The microenvironment of tumors is characterized by structural changes in the fibronectin matrix, which include increased deposition of the EDA isoform of fibronectin and the unfolding of the fibronectin Type...
3.
McKeown-Longo P, Higgins P
Adv Wound Care (New Rochelle)
. 2020 Jul;
10(3):137-152.
PMID: 32667849
Inflammation is a critical aspect of injury repair. Nonresolving inflammation, however, is perpetuated by the local generation of extracellular matrix-derived damage-associated molecular pattern molecules (DAMPs), such as the extra domain...
4.
Cho C, Horzempa C, Longo C, Peters D, Jones D, McKeown-Longo P
J Cancer
. 2020 Apr;
11(11):3099-3105.
PMID: 32231714
The microenvironment of solid tumors plays an essential role in tumor progression. In lung cancer, the stromal cells produce a fibronectin rich extracellular matrix which is known to contribute to...
5.
Zheng M, Ambesi A, McKeown-Longo P
Cells
. 2020 Jan;
9(1).
PMID: 31952223
Chronic inflammation and subsequent tissue fibrosis are associated with a biochemical and mechanical remodeling of the fibronectin matrix. Due to its conformational lability, fibronectin is considerably stretched by the contractile...
6.
McKeown-Longo P, Higgins P
Adv Wound Care (New Rochelle)
. 2017 Oct;
6(10):320-329.
PMID: 29062589
Chronic inflammation and maladaptive repair contribute to the development of fibrosis that negatively impacts quality of life and organ function. The toll-like receptor (TLR) system is a critical node in...
7.
Valenty L, Longo C, Horzempa C, Ambesi A, McKeown-Longo P
Adv Wound Care (New Rochelle)
. 2017 Oct;
6(10):309-319.
PMID: 29062588
Dysfunctional remodeling of the extracellular matrix contributes to the formation of TLR-dependent feed forward loops that drive chronic inflammation. We have previously shown that two Type III domains of Fibronectin,...
8.
Kelsh-Lasher R, Ambesi A, Bertram C, McKeown-Longo P
J Invest Dermatol
. 2017 Aug;
137(12):2505-2512.
PMID: 28842322
Alternative splicing of fibronectin increases expression of the EDA isoform of fibronectin (EDAFn), a damage-associated molecular pattern molecule, which promotes fibro-inflammatory disease through the activation of toll-like receptors. Our studies...
9.
Cho C, Kelsh-Lasher R, Ambesi A, McKeown-Longo P
Curr Top Pept Protein Res
. 2016 Aug;
16:37-47.
PMID: 27524870
The fibronectin matrix provides mechanical and biochemical information to regulate homeostatic and pathological processes within tissues. Fibronectin consists of independently-folded modules termed Types I, II and III. In response to...
10.
Cho C, Horzempa C, Jones D, McKeown-Longo P
BMC Cancer
. 2016 Aug;
16:574.
PMID: 27484721
Background: Fibronectin is a mechanically sensitive protein which is organized in the extracellular matrix as a network of interacting fibrils. The lung tumor stroma is enriched for fibronectin which is...