Paula Clemente
Overview
Explore the profile of Paula Clemente including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
296
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0
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Recent Articles
1.
Antolinez-Fernandez A, Esteban-Ramos P, Fernandez-Moreno M, Clemente P
Front Cell Dev Biol
. 2024 Jun;
12:1410245.
PMID: 38855161
Mitochondria play a central role in cellular metabolism producing the necessary ATP through oxidative phosphorylation. As a remnant of their prokaryotic past, mitochondria contain their own genome, which encodes 13...
2.
Gonzalez C, Martinez-Sanchez L, Clemente P, Toivonen J, Arredondo J, Fernandez-Moreno M, et al.
FEBS Open Bio
. 2023 Nov;
14(2):276-289.
PMID: 38013241
Mitochondrial carrier homologs 1 (MTCH1) and 2 (MTCH2) are orphan members of the mitochondrial transporter family SLC25. Human MTCH1 is also known as presenilin 1-associated protein, PSAP. MTCH2 is a...
3.
Clemente P, Calvo-Garrido J, Pearce S, Schober F, Shigematsu M, Siira S, et al.
Nat Commun
. 2022 Sep;
13(1):5750.
PMID: 36180430
Canonical RNA processing in mammalian mitochondria is defined by tRNAs acting as recognition sites for nucleases to release flanking transcripts. The relevant factors, their structures, and mechanism are well described,...
4.
Rosenberger F, Moore D, Atanassov I, Moedas M, Clemente P, Vegvari A, et al.
Sci Adv
. 2021 Feb;
7(8).
PMID: 33608280
Induction of the one-carbon cycle is an early hallmark of mitochondrial dysfunction and cancer metabolism. Vital intermediary steps are localized to mitochondria, but it remains unclear how one-carbon availability connects...
5.
Pajak A, Laine I, Clemente P, El-Fissi N, Schober F, Maffezzini C, et al.
PLoS Genet
. 2019 Aug;
15(7):e1008240.
PMID: 31365523
The RNA helicase SUV3 and the polynucleotide phosphorylase PNPase are involved in the degradation of mitochondrial mRNAs but their roles in vivo are not fully understood. Additionally, upstream processes, such...
6.
Maffezzini C, Laine I, Dallabona C, Clemente P, Calvo-Garrido J, Wibom R, et al.
Mol Genet Genomic Med
. 2019 Mar;
7(6):e654.
PMID: 30920170
Background: Mutations in mitochondrial aminoacyl tRNA synthetases form a subgroup of mitochondrial disorders often only perturbing brain function by affecting mitochondrial translation. Here we report two siblings with mitochondrial disease,...
7.
Olive M, Engvall M, Ravenscroft G, Cabrera-Serrano M, Jiao H, Bortolotti C, et al.
Nat Commun
. 2019 Mar;
10(1):1396.
PMID: 30918256
Myoglobin, encoded by MB, is a small cytoplasmic globular hemoprotein highly expressed in cardiac myocytes and oxidative skeletal myofibers. Myoglobin binds O facilitates its intracellular transport and serves as a...
8.
Calvo-Garrido J, Maffezzini C, Schober F, Clemente P, Uhlin E, Kele M, et al.
Stem Cell Reports
. 2019 Mar;
12(4):696-711.
PMID: 30827875
Neurodegenerative disorders are an increasingly common and irreversible burden on society, often affecting the aging population, but their etiology and disease mechanisms are poorly understood. Studying monogenic neurodegenerative diseases with...
9.
Siibak T, Clemente P, Bratic A, Bruhn H, Kauppila T, Macao B, et al.
Hum Mol Genet
. 2017 Apr;
26(13):2515-2525.
PMID: 28430993
Mutations in the mitochondrial DNA polymerase, POLG, are associated with a variety of clinical presentations, ranging from early onset fatal brain disease in Alpers syndrome to chronic progressive external ophthalmoplegia....
10.
Neira J, Martinez-Rodriguez S, Hernandez-Cifre J, Camara-Artigas A, Clemente P, Peralta S, et al.
Biochemistry
. 2016 Oct;
55(45):6209-6220.
PMID: 27791355
The assembly of the protein complex of cytochrome c oxidase (COX), which participates in the mitochondrial respiratory chain, requires a large number of accessory proteins (the so-called assembly factors). Human...