Paul Zumbo
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Explore the profile of Paul Zumbo including associated specialties, affiliations and a list of published articles.
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49
Citations
5350
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Recent Articles
1.
Herrera A, Leyre L, Weiler J, Linden N, Huynh T, Wang F, et al.
bioRxiv
. 2025 Jan;
PMID: 39763858
Cytotoxic T-lymphocytes (CTL) exert sustained pressure on reservoirs of HIV-infected cells that persist through years of antiretroviral therapy (ART). This selects for latently infected cells, but also potentially for cells...
2.
Cortada E, Yao J, Xia Y, Dundar F, Zumbo P, Yang B, et al.
Commun Biol
. 2024 Dec;
7(1):1611.
PMID: 39627536
The immune system coordinates the response to cardiac injury and controls regenerative and fibrotic scar outcomes in the heart and subsequent chronic low-grade inflammation associated with heart failure. Adult mice...
3.
Guo Y, Aufiero M, Mills K, Grassmann S, Kim H, Zumbo P, et al.
bioRxiv
. 2024 Nov;
PMID: 39484591
Aspergillus fumigatus is the most common cause of invasive aspergillosis (IA), a devastating infection in immunocompromised patients. Plasmacytoid dendritic cells (pDCs) regulate host defense against IA by enhancing neutrophil antifungal...
4.
Nease L, Church K, Delclaux I, Murakami S, Astorkia M, Zerhouni M, et al.
Nat Cancer
. 2024 Oct;
5(12):1868-1884.
PMID: 39438623
Selenocysteine-containing proteins play a central role in redox homeostasis. Their translation is a highly regulated process and is dependent on two tRNA isodecoders differing by a single 2'-O-ribose methylation called...
5.
Espinosa-Carrasco G, Chiu E, Scrivo A, Zumbo P, Dave A, Betel D, et al.
Cancer Cell
. 2024 Jun;
42(7):1202-1216.e8.
PMID: 38906155
Tumor-specific CD8 T cells are frequently dysfunctional and unable to halt tumor growth. We investigated whether tumor-specific CD4 T cells can be enlisted to overcome CD8 T cell dysfunction within...
6.
Yi F, Cohen T, Zimmerman N, Dundar F, Zumbo P, Eltilib R, et al.
bioRxiv
. 2024 Mar;
PMID: 38464085
Chimeric antigen receptor (CAR)-engineered T and NK cells can cause durable remission of B-cell malignancies; however, limited persistence restrains the full potential of these therapies in many patients. The FAS...
7.
Falvo D, Grimont A, Zumbo P, Fall W, Yang J, Osterhoudt A, et al.
Dev Cell
. 2023 Dec;
58(24):2959-2973.e7.
PMID: 38056453
Inflammation is essential to the disruption of tissue homeostasis and can destabilize the identity of lineage-committed epithelial cells. Here, we employ lineage-traced mouse models, single-cell transcriptomic and chromatin analyses, and...
8.
Copertino Jr D, Holmberg C, Weiler J, Ward A, Howard J, Levinger C, et al.
JCI Insight
. 2023 Aug;
8(18).
PMID: 37581929
IL-15 is under clinical investigation toward the goal of curing HIV infection because of its abilities to reverse HIV latency and enhance immune effector function. However, increased potency through combination...
9.
Rudloff M, Zumbo P, Favret N, Roetman J, Detres Roman C, Erwin M, et al.
Nat Immunol
. 2023 Aug;
24(9):1527-1539.
PMID: 37537361
Tumor-specific CD8+ T cells (TST) in patients with cancer are dysfunctional and unable to halt cancer progression. TST dysfunction, also known as exhaustion, is thought to be driven by chronic...
10.
Espinosa-Carrasco G, Scrivo A, Zumbo P, Dave A, Betel D, Hellmann M, et al.
bioRxiv
. 2023 Jul;
PMID: 37461721
Tumor-reactive CD8 T cells found in cancer patients are frequently dysfunctional, unable to halt tumor growth. Adoptive T cell transfer (ACT), the administration of large numbers of -generated cytolytic tumor-reactive...