Paul Yan
Overview
Explore the profile of Paul Yan including associated specialties, affiliations and a list of published articles.
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8
Citations
360
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Recent Articles
1.
McGaw C, Garrity A, Munoz G, Haswell J, Sengupta S, Keston-Smith E, et al.
Nat Commun
. 2022 May;
13(1):2833.
PMID: 35595757
The CRISPR-Cas type V-I is a family of Cas12i-containing programmable nuclease systems guided by a short crRNA without requirement for a tracrRNA. Here we present an engineered Type V-I CRISPR...
2.
Subramanian B, Chun J, Perez-Gill C, Yan P, Stillman I, Higgs H, et al.
J Am Soc Nephrol
. 2020 Jan;
31(2):374-391.
PMID: 31924668
Background: Mutations in the gene encoding inverted formin-2 (INF2), a member of the formin family of actin regulatory proteins, are among the most common causes of autosomal dominant FSGS. INF2...
3.
Alterman J, Godinho B, Hassler M, Ferguson C, Echeverria D, Sapp E, et al.
Nat Biotechnol
. 2019 Aug;
37(8):884-894.
PMID: 31375812
Sustained silencing of gene expression throughout the brain using small interfering RNAs (siRNAs) has not been achieved. Here we describe an siRNA architecture, divalent siRNA (di-siRNA), that supports potent, sustained...
4.
Pai A, Paggi J, Yan P, Adelman K, Burge C
PLoS Genet
. 2018 Aug;
14(8):e1007588.
PMID: 30148878
Recursive splicing, a process by which a single intron is removed from pre-mRNA transcripts in multiple distinct segments, has been observed in a small subset of Drosophila melanogaster introns. However,...
5.
Zhang J, Wang M, Tian L, Genovese G, Yan P, Wilson J, et al.
Proc Natl Acad Sci U S A
. 2018 Mar;
115(13):3446-3451.
PMID: 29531077
People of recent African ancestry develop kidney disease at much higher rates than most other groups. Two specific coding variants in the Apolipoprotein-L1 gene termed G1 and G2 are the...
6.
Subramanian B, Sun H, Yan P, Charoonratana V, Higgs H, Wang F, et al.
Kidney Int
. 2016 Jun;
90(2):363-372.
PMID: 27350175
Mutations in the INF2 (inverted formin 2) gene, encoding a diaphanous formin family protein that regulates actin cytoskeleton dynamics, cause human focal segmental glomerulosclerosis (FSGS). INF2 interacts directly with certain...
7.
Olabisi O, Zhang J, VerPlank L, Zahler N, DiBartolo 3rd S, Heneghan J, et al.
Proc Natl Acad Sci U S A
. 2015 Dec;
113(4):830-7.
PMID: 26699492
Two specific genetic variants of the apolipoprotein L1 (APOL1) gene are responsible for the high rate of kidney disease in people of recent African ancestry. Expression in cultured cells of...
8.
Molday L, Djajadi H, Yan P, Szczygiel L, Boye S, Chiodo V, et al.
Hum Mol Genet
. 2013 Jun;
22(19):3894-905.
PMID: 23740938
RD3 is a 23 kDa protein implicated in the stable expression of guanylate cyclase in photoreceptor cells. Truncation mutations are responsible for photoreceptor degeneration and severe early-onset vision loss in...