Paul W Dempsey
Overview
Explore the profile of Paul W Dempsey including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
1345
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Recent Articles
11.
Shimada K, Chen S, Dempsey P, Sorrentino R, Alsabeh R, Slepenkin A, et al.
PLoS Pathog
. 2009 Apr;
5(4):e1000379.
PMID: 19360122
Here we investigated the role of the Nod/Rip2 pathway in host responses to Chlamydophila pneumoniae-induced pneumonia in mice. Rip2(-/-) mice infected with C. pneumoniae exhibited impaired iNOS expression and NO...
12.
Zarnegar B, Wang Y, Mahoney D, Dempsey P, Cheung H, He J, et al.
Nat Immunol
. 2008 Nov;
9(12):1371-8.
PMID: 18997794
Recent studies suggest that nuclear factor kappaB-inducing kinase (NIK) is suppressed through constitutive proteasome-mediated degradation regulated by TRAF2, TRAF3 and cIAP1 or cIAP2. Here we demonstrated that the degradation of...
13.
He J, Zarnegar B, Oganesyan G, Saha S, Yamazaki S, Doyle S, et al.
J Exp Med
. 2006 Oct;
203(11):2413-8.
PMID: 17015635
Proper activation of nuclear factor (NF)-kappaB transcription factors is critical in regulating fundamental biological processes such as cell survival and proliferation, as well as in inflammatory and immune responses. Recently,...
14.
OConnell R, Vaidya S, Perry A, Saha S, Dempsey P, Cheng G
J Immunol
. 2005 Jan;
174(3):1602-7.
PMID: 15661922
Type I IFNs are well established antiviral cytokines that have also been shown to be induced by bacteria. However, the signaling mechanisms regulating the activation of these cytokines during bacterial...
15.
Liu B, Mink S, Wong K, Stein N, Getman C, Dempsey P, et al.
Nat Immunol
. 2004 Aug;
5(9):891-8.
PMID: 15311277
Interferon (IFN) activates the signal transducer and activator of transcription (STAT) pathway to regulate immune responses. The protein inhibitor of activated STAT (PIAS) family has been suggested to negatively regulate...
16.
Dempsey P, Doyle S, He J, Cheng G
Cytokine Growth Factor Rev
. 2003 Jun;
14(3-4):193-209.
PMID: 12787559
Members of the TNF receptor superfamily play pivotal roles in numerous biological events in metazoan organisms. Ligand-mediated trimerization by corresponding homo- or heterotrimeric ligands, the TNF family ligands, causes recruitment...
17.
Chin A, Dempsey P, Bruhn K, Miller J, Xu Y, Cheng G
Nature
. 2002 Mar;
416(6877):190-4.
PMID: 11894097
Host defences to microorganisms rely on a coordinated interplay between the innate and adaptive responses of immunity. Infection with intracellular bacteria triggers an immediate innate response requiring macrophages, neutrophils and...