Paul Schofield
Overview
Explore the profile of Paul Schofield including associated specialties, affiliations and a list of published articles.
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38
Citations
1028
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Recent Articles
11.
Scott J, Bowker S, Brocklehurst K, Brown H, Clarke D, Easter A, et al.
J Med Chem
. 2014 Oct;
57(21):8984-98.
PMID: 25286150
Agonism of GPR119 is viewed as a potential therapeutic approach for the treatment of type II diabetes and other elements of metabolic syndrome. During progression of a previously disclosed candidate...
12.
Kohler S, Doelken S, Ruef B, Bauer S, Washington N, Westerfield M, et al.
F1000Res
. 2014 Feb;
2:30.
PMID: 24358873
Phenotype analyses, e.g. investigating metabolic processes, tissue formation, or organism behavior, are an important element of most biological and medical research activities. Biomedical researchers are making increased use of ontological...
13.
Kohler S, Doelken S, Mungall C, Bauer S, Firth H, Bailleul-Forestier I, et al.
Nucleic Acids Res
. 2013 Nov;
42(Database issue):D966-74.
PMID: 24217912
The Human Phenotype Ontology (HPO) project, available at http://www.human-phenotype-ontology.org, provides a structured, comprehensive and well-defined set of 10,088 classes (terms) describing human phenotypic abnormalities and 13,326 subclass relations between the...
14.
Scott J, Brocklehurst K, Brown H, Clarke D, Coe H, Groombridge S, et al.
Bioorg Med Chem Lett
. 2013 May;
23(11):3175-9.
PMID: 23628336
A series of conformationally restricted GPR119 agonists were prepared based around a 3,8-diazabicyclo[3.2.1]octane scaffold. Examples were found to have markedly different pharmacology in mouse and human despite similar levels of...
15.
Addink W, Aelterman B, Agosti D, Amaral-Zettler L, Arino A, Arvanitidis C, et al.
BMC Ecol
. 2013 Apr;
13:16.
PMID: 23587026
Biodiversity informatics plays a central enabling role in the research community's efforts to address scientific conservation and sustainability issues. Great strides have been made in the past decade establishing a...
16.
Gaudet P, Arighi C, Bastian F, Bateman A, Blake J, Cherry M, et al.
Database (Oxford)
. 2012 Nov;
2012:bas036.
PMID: 23110974
The 5th International Biocuration Conference brought together over 300 scientists to exchange on their work, as well as discuss issues relevant to the International Society for Biocuration's (ISB) mission. Recurring...
17.
Scott J, Gill A, Godfrey L, Groombridge S, Rees A, Revill J, et al.
Bioorg Med Chem Lett
. 2012 Sep;
22(21):6756-61.
PMID: 23013933
11β-HSD1 is increasingly seen as an attractive target for the treatment of type II diabetes and other elements of the metabolic syndrome. In this program of work we describe how...
18.
Bradley A, Anastassiadis K, Ayadi A, Battey J, Bell C, Birling M, et al.
Mamm Genome
. 2012 Sep;
23(9-10):580-6.
PMID: 22968824
In 2007, the International Knockout Mouse Consortium (IKMC) made the ambitious promise to generate mutations in virtually every protein-coding gene of the mouse genome in a concerted worldwide action. Now,...
19.
Scott J, Bowker S, deSchoolmeester J, Gerhardt S, Hargreaves D, Kilgour E, et al.
J Med Chem
. 2012 Jun;
55(12):5951-64.
PMID: 22691057
Inhibition of 11β-HSD1 is an attractive mechanism for the treatment of obesity and other elements of the metabolic syndrome. We report here the discovery of a nicotinic amide derived carboxylic...
20.
McCoull W, Addie M, Birch A, Birtles S, Buckett L, Butlin R, et al.
Bioorg Med Chem Lett
. 2012 May;
22(12):3873-8.
PMID: 22608962
A novel series of DGAT-1 inhibitors was discovered from an oxadiazole amide high throughput screening (HTS) hit. Optimisation of potency and ligand lipophilicity efficiency (LLE) resulted in a carboxylic acid...