Paul R Lockman
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Explore the profile of Paul R Lockman including associated specialties, affiliations and a list of published articles.
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73
Citations
2392
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Recent Articles
1.
Arsiwala T, Blethen K, Wolford C, Pecar G, Panchal D, Kielkowski B, et al.
Pharmaceutics
. 2025 Jan;
17(1).
PMID: 39861723
The blood-brain barrier (BBB) is selectively permeable, but it also poses significant challenges for treating CNS diseases. Low-intensity focused ultrasound (LiFUS), paired with microbubbles is a promising, non-invasive technique for...
2.
Arsiwala T, Blethen K, Wolford C, Panchal D, Sprowls S, Fladeland R, et al.
Front Oncol
. 2023 Feb;
13:1104594.
PMID: 36845739
Patients with metastatic breast cancer have high and continually increasing rates of brain metastases. During the course of the disease, brain metastases can occur in up to 30% of these...
3.
Arsiwala T, Sprowls S, Blethen K, Fladeland R, Wolford C, Kielkowski B, et al.
Fluids Barriers CNS
. 2022 Sep;
19(1):72.
PMID: 36076213
Background: Systemic drug delivery to the central nervous system is limited by presence of the blood-brain barrier (BBB). Low intensity focused ultrasound (LiFUS) is a non-invasive technique to disrupt the...
4.
Walker 2nd W, Sprowls S, Bumgarner J, Liu J, Melendez-Fernandez O, Walton J, et al.
Front Oncol
. 2021 Dec;
11:752331.
PMID: 34956876
Chemotherapy is more effective in the treatment of peripheral tumors than brain metastases, likely reflecting the reduced ability of chemotherapy to cross the blood-brain barrier (BBB) and blood-tumor barrier at...
5.
Blethen K, Arsiwala T, Fladeland R, Sprowls S, Panchal D, Adkins C, et al.
Neurooncol Adv
. 2021 Dec;
3(Suppl 5):v133-v143.
PMID: 34859240
The blood-brain barrier is the selectively permeable vasculature of the brain vital for maintaining homeostasis and neurological function. Low permeability is beneficial in the presence of toxins and pathogens in...
6.
Overcoming the acquired resistance to gefitinib in lung cancer brain metastasis in vitro and in vivo
Liu Z, Shah N, Marshall K, Sprowls S, Saralkar P, Mohammad A, et al.
Arch Toxicol
. 2021 Aug;
95(11):3575-3587.
PMID: 34455456
In our previous work, PC-9-Br, a PC-9 brain seeking line established via a preclinical animal model of lung cancer brain metastasis (LCBM), exhibited not only resistance to epidermal growth factor...
7.
Klein A, Nugent G, Cavendish J, Geldenhuys W, Sriram K, Porter D, et al.
Pharmaceutics
. 2021 Jul;
13(7).
PMID: 34202660
The rapid growth of nanotechnology and the development of novel nanomaterials with unique physicochemical characteristics provides potential for the utility of nanomaterials in theranostics, including neuroimaging, for identifying neurodegenerative changes...
8.
Sprowls S, Saralkar P, Arsiwala T, Adkins C, Blethen K, Pizzuti V, et al.
Pharmaceutics
. 2021 Jun;
13(5).
PMID: 34069733
The blood-brain barrier (BBB) limits movement of solutes from the lumen of the brain microvascular capillary system into the parenchyma. The unidirectional transfer constant, , is the rate at which...
9.
Sprowls S, Pizzuti V, Pentz W, Nwafor D, Siochi R, Lockman P
J Vis Exp
. 2021 Mar;
(169).
PMID: 33779614
Radiation dosimetry is critical in the accurate delivery and reproducibility of radiation schemes in preclinical models for high translational relevance. Prior to performing any in vitro or in vivo experiments,...
10.
Shah N, Liu Z, Tallman R, Mohammad A, Sprowls S, Saralkar P, et al.
BMC Cancer
. 2020 Apr;
20(1):292.
PMID: 32264860
Background: Cancer metastasis and drug resistance have traditionally been studied separately, though these two lethal pathological phenomena almost always occur concurrently. Brain metastasis occurs in a large proportion of lung...