Paul Peter Tak
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Explore the profile of Paul Peter Tak including associated specialties, affiliations and a list of published articles.
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37
Citations
1488
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Recent Articles
1.
Mariette X, Barone F, Baldini C, Bootsma H, Clark K, De Vita S, et al.
JCI Insight
. 2022 Dec;
7(23).
PMID: 36477362
BACKGROUNDPrimary Sjögren's syndrome (pSS) is characterized by B cell hyperactivity and elevated B-lymphocyte stimulator (BLyS). Anti-BLyS treatment (e.g., belimumab) increases peripheral memory B cells; decreases naive, activated, and plasma B...
2.
Koch M, Zdioruk M, Nowicki M, Griffith A, Aguilar-Cordova E, Aguilar L, et al.
Mol Ther Oncolytics
. 2022 Aug;
26:275-288.
PMID: 36032633
CAN-2409 is a replication-deficient adenovirus encoding herpes simplex virus (HSV) thymidine kinase (tk) currently in clinical trials for treatment of glioblastoma. The expression of tk in transduced cancer cells results...
3.
Weisel K, Scott N, Berger S, Wang S, Brown K, Powell M, et al.
BMJ Open Gastroenterol
. 2021 Aug;
8(1).
PMID: 34389633
Objective: Tumour necrosis factor signalling via the receptor-interacting protein kinase 1 (RIPK1) pathway regulates colonic inflammation suggesting that RIPK1 inhibition may be a potential therapeutic target in ulcerative colitis (UC)....
4.
Weisel K, Berger S, Thorn K, Taylor P, Peterfy C, Siddall H, et al.
Arthritis Res Ther
. 2021 Mar;
23(1):85.
PMID: 33726834
Background: Receptor-interacting protein kinase 1 (RIPK1) is a key mediator of inflammation through cell death and proinflammatory cytokine production. This multicenter, randomized, double-blind (sponsor-unblinded), placebo-controlled, experimental medicine study evaluated the...
5.
Ramos M, Garcia S, Helder B, Aarrass S, Reedquist K, Jacobsen S, et al.
J Transl Autoimmun
. 2020 Oct;
3:100066.
PMID: 33015599
Rheumatoid arthritis (RA) is chronic autoimmune disease which etiology remains unknown. Several cell types have been described to potentiate/aggravate the arthritic process however the initiating event in synovial inflammation is...
6.
Weisel K, Berger S, Papp K, Maari C, Krueger J, Scott N, et al.
Clin Pharmacol Ther
. 2020 Apr;
108(4):808-816.
PMID: 32301501
Receptor-interacting protein kinase 1 (RIPK1), a regulator of inflammation and cell death, is a potential therapeutic target in immune-mediated inflammatory diseases (IMIDs). The objective of this phase IIa multicenter, randomized,...
7.
Quistrebert J, Hassler S, Bachelet D, Mbogning C, Musters A, Tak P, et al.
Semin Arthritis Rheum
. 2018 Nov;
48(6):967-975.
PMID: 30420245
Objectives: To evaluate the incidence of anti-drug antibody (ADA) occurrences and ADA-related risk factors under adalimumab and infliximab treatment in rheumatoid arthritis (RA) patients. Methods: The study combined retrospective cohorts...
8.
Tang M, Koopman F, Visscher J, de Hair M, Gerlag D, Tak P
Clin Rheumatol
. 2016 Nov;
36(2):269-278.
PMID: 27807638
Rheumatoid arthritis (RA) is a chronic autoimmune disease associated with changes in several hormones and metabolic peptides. Crosstalk between these factors and the immune system may be important for homeostasis...
9.
Schilderink R, Bell M, Reginato E, Patten C, Rioja I, Hilbers F, et al.
Mol Immunol
. 2016 Oct;
79:66-76.
PMID: 27710838
Transcription of inflammatory genes is tightly regulated by acetylation and deacetylation of histone tails. An inhibitor of the acetylated-lysine reader bromodomain and extra-terminal domain (BET) proteins, I-BET151, is known to...
10.
Maijer K, Gudmann N, Karsdal M, Gerlag D, Tak P, Bay-Jensen A
PLoS One
. 2016 Mar;
11(3):e0149329.
PMID: 27019199
Objective: Tissue destruction in rheumatoid arthritis (RA) is predominantly mediated by matrix metalloproteinases (MMPs), thereby generating protein fragments. Previous studies have revealed that these fragments include MMP-mediated collagen type I,...