Paul Nicklin
Overview
Explore the profile of Paul Nicklin including associated specialties, affiliations and a list of published articles.
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18
Citations
1392
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Recent Articles
1.
Thoma G, Miltz W, Waelchli R, Orain D, Spanka C, Decoret O, et al.
J Med Chem
. 2025 Feb;
68(4):4721-4742.
PMID: 39960261
Leukotriene C4 synthase (LTC4S) is a glutathione -transferase that mediates the biosynthesis of cysteinyl leukotriene C4 (LTC4). Cysteinyl leukotrienes (CysLTs) are lipid mediators that drive type 2 inflammation, bronchoconstriction, and...
2.
Mei M, Impagnatiello M, Jiao J, Reiser U, Tontsch-Grunt U, Zhang J, et al.
Protein Cell
. 2023 Jun;
15(1):69-75.
PMID: 37294910
No abstract available.
3.
Liu Y, Nicklin P, He Y
Viruses
. 2022 Jun;
14(6).
PMID: 35746616
Immune homeostasis is achieved by balancing the activating and inhibitory signal transduction pathways mediated via cell surface receptors. Activation allows the host to mount an immune response to endogenous and...
4.
Gollner A, Koster M, Nicklin P, Trieselmann T, Klein E, Vlach J, et al.
Nat Rev Drug Discov
. 2022 Apr;
21(7):475-476.
PMID: 35459938
No abstract available.
5.
Yang Y, Santos D, Pantano L, Knipe R, Abe E, Logue A, et al.
Am J Respir Cell Mol Biol
. 2022 Apr;
67(1):36-49.
PMID: 35377835
Idiopathic pulmonary fibrosis is a progressive lung disease with limited therapeutic options that is characterized by pathological fibroblast activation and aberrant lung remodeling with scar formation. YAP (Yes-associated protein) is...
6.
Jerke U, Eulenberg-Gustavus C, Rousselle A, Nicklin P, Kreideweiss S, Grundl M, et al.
J Am Soc Nephrol
. 2022 Mar;
33(5):936-947.
PMID: 35292437
Background: The ANCA autoantigens proteinase 3 (PR3) and myeloperoxidase (MPO) are exclusively expressed by neutrophils and monocytes. ANCA-mediated activation of these cells is the key driver of the vascular injury...
7.
Bellenie B, Hall E, Bruce I, Spendiff M, Culshaw A, McDonald S, et al.
J Med Chem
. 2021 Aug;
64(16):12304-12321.
PMID: 34384024
Using a novel physiologically relevant in vitro human whole blood neutrophil shape change assay, an aminopyrazine series of selective PI3Kγ inhibitors was identified and prioritized for further optimization. Severe solubility...
8.
Escrevente C, Falcao A, Hall M, Lopes-da-Silva M, Antas P, Mesquita M, et al.
Invest Ophthalmol Vis Sci
. 2021 Jul;
62(9):39.
PMID: 34313720
Purpose: We aim to characterize the pathways required for autofluorescent granule (AFG) formation by RPE cells using cultured monolayers. Methods: We fed RPE monolayers in culture with a single pulse...
9.
Santos D, Pantano L, Pronzati G, Grasberger P, Probst C, Black K, et al.
Am J Respir Cell Mol Biol
. 2020 Jan;
62(4):479-492.
PMID: 31944822
Idiopathic pulmonary fibrosis is a lung disease with limited therapeutic options that is characterized by pathological fibroblast activation and aberrant lung remodeling with scar formation. YAP (Yes-associated protein) is a...
10.
Bigaeva E, Gore E, Simon E, Zwick M, Oldenburger A, de Jong K, et al.
Arch Toxicol
. 2019 Nov;
93(12):3549-3583.
PMID: 31754732
Our knowledge of complex pathological mechanisms underlying organ fibrosis is predominantly derived from animal studies. However, relevance of animal models for human disease is limited; therefore, an ex vivo model...